Caspase-2 Antibody (11B4) - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-80096

Novus Biologicals, part of Bio-Techne

Key Product Details

Species Reactivity

Human, Mouse, Rat, Canine, Monkey

Applications

ELISA, Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Rat IgG2a Kappa Clone # 11B4

Format

BSA Free

Concentration

1 mg/ml

View all Caspase-2 Antibodies »

Product Specifications

Immunogen

Recombinant human caspase-2 (p19 subunit).

Specificity

Recognizes an epitope in the p19 subunit of human, mouse, rat, monkey and dog caspase-2. Detects bands of ~51kDa (procaspase-2), ~32kDa and ~18kDa (cleavage products) by Western blot.

Clonality

Monoclonal

Host

Rat

Isotype

IgG2a Kappa

Description

Novus Biologicals Rat Caspase-2 Antibody (11B4) - BSA Free (NBP2-80096) is a monoclonal antibody validated for use in IHC, WB, ELISA, Flow, ICC/IF and IP. All Novus Biologicals antibodies are covered by our 100% guarantee.

Scientific Data Images for Caspase-2 Antibody (11B4) - BSA Free

Western Blot: Caspase-2 Antibody (11B4)BSA Free [NBP2-80096]

Western Blot: Caspase-2 Antibody (11B4)BSA Free [NBP2-80096]

Western Blot: Caspase-2 Antibody (11B4) - BSA Free [NBP2-80096] - Analysis using Caspase-2, mAb (11B4) (Prod. No. NBP2-80096)
Immunoprecipitation: Caspase-2 Antibody (11B4) - BSA Free [NBP2-80096]

Immunoprecipitation: Caspase-2 Antibody (11B4) - BSA Free [NBP2-80096]

Immunoprecipitation: Caspase-2 Antibody (11B4) - BSA Free [NBP2-80096] - Using Caspase-2, mAb (11B4) (Prod. No. NBP2-80096)

Applications for Caspase-2 Antibody (11B4) - BSA Free

Application
Recommended Usage

ELISA

Optimal dilutions of this antibody should be experimentally determined.

Flow Cytometry

Optimal dilutions of this antibody should be experimentally determined.

Immunocytochemistry/ Immunofluorescence

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry

Optimal dilutions of this antibody should be experimentally determined.

Immunoprecipitation

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

PBS

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Caspase-2

Caspase-2, also known as NEDD2 and ICH-1, is a 30‑32 kDa member of the peptidase C14A/IL‑1 beta‑converting family of enzymes. It is widely expressed and is an integral component of the apoptotic cascade. Caspase-2 is a disulfide-linked homodimer, with activation occurring following oligomerization within the context of activating platforms such as DISC (death-inducing signaling complex) or the PIDDosome. Initially, Pro-Caspase-2 is cleaved into a p34 subunit and a p14 subunit which are further processed to generate the prodomain, plus the mature p18 and p12 subunits. Notably, each p18-p12 heterodimer demonstrates proteolytic activity and localizes to either the nucleus or cytoplasm.

 

Alternate Names

CASP2, Caspase2, ICH-1, NEDD2

Gene Symbol

CASP2

Additional Caspase-2 Products

Product Documents for Caspase-2 Antibody (11B4) - BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Caspase-2 Antibody (11B4) - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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