Caspase-2 Antibody (10C6) - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-80095

Novus Biologicals, part of Bio-Techne

Key Product Details

Species Reactivity

Human, Mouse, Rat, Canine, Monkey

Applications

ELISA, Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry

Label

Unconjugated

Antibody Source

Monoclonal Rat IgG2a Kappa Clone # 10C6

Format

BSA Free

Concentration

1 mg/ml

View all Caspase-2 Antibodies »

Product Specifications

Immunogen

Recombinant human caspase-2 (p19 subunit).

Specificity

Recognizes an epitope in the p19 subunit of human, mouse, rat, monkey and dog caspase-2.

Clonality

Monoclonal

Host

Rat

Isotype

IgG2a Kappa

Description

Novus Biologicals Rat Caspase-2 Antibody (10C6) - BSA Free (NBP2-80095) is a monoclonal antibody validated for use in IHC, ELISA, Flow and ICC/IF. All Novus Biologicals antibodies are covered by our 100% guarantee.

Scientific Data Images for Caspase-2 Antibody (10C6) - BSA Free

Immunocytochemistry/ Immunofluorescence: Caspase-2 Antibody (10C6) - BSA Free [NBP2-80095]

Immunocytochemistry/ Immunofluorescence: Caspase-2 Antibody (10C6) - BSA Free [NBP2-80095]

Immunocytochemistry/Immunofluorescence: Caspase-2 Antibody (10C6) - BSA Free [NBP2-80095] - HeLa cells were fixed, permeabilised, stained using Caspase-2, mAb (10C6) (Prod. No. NBP2-80095)
Flow Cytometry: Caspase-2 Antibody (10C6) - BSA Free [NBP2-80095]

Flow Cytometry: Caspase-2 Antibody (10C6) - BSA Free [NBP2-80095]

Flow Cytometry: Caspase-2 Antibody (10C6) - BSA Free [NBP2-80095] - Data of 293T cells transiently transfected with HA-tagged caspase-2, fixed with 1% PFA, permeabilized with saponin and stained intracellularly with using Caspase-2, mAb (10C6) (Prod. No.NBP2-80095)

Applications for Caspase-2 Antibody (10C6) - BSA Free

Application
Recommended Usage

ELISA

Optimal dilutions of this antibody should be experimentally determined.

Flow Cytometry

Optimal dilutions of this antibody should be experimentally determined.

Immunocytochemistry/ Immunofluorescence

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry

Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

PBS

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Caspase-2

Caspase-2, also known as NEDD2 and ICH-1, is a 30‑32 kDa member of the peptidase C14A/IL‑1 beta‑converting family of enzymes. It is widely expressed and is an integral component of the apoptotic cascade. Caspase-2 is a disulfide-linked homodimer, with activation occurring following oligomerization within the context of activating platforms such as DISC (death-inducing signaling complex) or the PIDDosome. Initially, Pro-Caspase-2 is cleaved into a p34 subunit and a p14 subunit which are further processed to generate the prodomain, plus the mature p18 and p12 subunits. Notably, each p18-p12 heterodimer demonstrates proteolytic activity and localizes to either the nucleus or cytoplasm.

 

Alternate Names

CASP2, Caspase2, ICH-1, NEDD2

Gene Symbol

CASP2

Additional Caspase-2 Products

Product Documents for Caspase-2 Antibody (10C6) - BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Caspase-2 Antibody (10C6) - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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