Androgen Receptor V7 Antibody (DHTR.V7/9394R) - Azide and BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-24295

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne

Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Monoclonal Rabbit IgG Kappa Clone # DHTR.V7/9394R

Format

Azide and BSA Free

Concentration

1 mg/ml

View all Androgen Receptor V7 Antibodies »

Product Specifications

Immunogen

Recombinant fragment (around aa600-920) of human Androgen Receptor-protein (Androgen Receptor-V7 specific) (exact sequence is proprietary)

Localization

Nucleus.

Specificity

AR V7 belongs to the nuclear hormone receptor family. It contains the nuclear receptor DNA binding domain. Steroid hormone receptors are ligand-activated transcription factors that regulate the expression of eukaryotic genes affecting cell proliferation and differentiation in target tissues. The activity of transcription factors is regulated by binding co-activators and co-repressors. This target is a splice variant of the androgen receptor that lacks the C-terminal androgen-binding site. AR-V7 plays an important role in the occurrence, development and drug resistance of prostate cancer.

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG Kappa

Description

Antibody without azide - store at -20 to -80C.

Scientific Data Images for Androgen Receptor V7 Antibody (DHTR.V7/9394R) - Azide and BSA Free

Androgen Receptor V7 Antibody (DHTR.V7/9394R) - Azide and BSA Free Immunohistochemistry-Paraffin: Androgen Receptor V7 Antibody (DHTR.V7/9394R) - Azide and BSA Free [NBP3-24295] -

Immunohistochemistry-Paraffin: Androgen Receptor V7 Antibody (DHTR.V7/9394R) - Azide and BSA Free [NBP3-24295] -

Immunohistochemistry-Paraffin: Androgen Receptor V7 Antibody (DHTR.V7/9394R) - Azide and BSA Free [NBP3-24295] - Formalin-fixed, paraffin-embedded human prostate carcinoma stained with Androgen Receptor V7 Antibody (DHTR.V7/9394R). HIER: Tris/EDTA, pH9.0, 95°C/45min. 2°CAb: HRP-Poly:30min. DAB:5min.

Applications for Androgen Receptor V7 Antibody (DHTR.V7/9394R) - Azide and BSA Free

Application
Recommended Usage

Immunohistochemistry-Paraffin

1-2ug/ml
Application Notes
Immunohistochemistry-Paraffin: 1-2ug/ml for 30 minutes at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95C followed by cooling at RT for 20 minutes. Optimal dilution for a specific application should be determined.

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

10mM PBS

Format

Azide and BSA Free

Preservative

No Preservative

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20 to -80C. Avoid freeze-thaw cycles.

Background: Androgen Receptor V7

The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract from the normal 9-34 repeats to the pathogenic 38-62 repeats causes spinal bulbar muscular atrophy (SBMA, also known as Kennedy's disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Alternative splicing results in multiple transcript variants encoding different isoforms.

Alternate Names

AIS, androgen receptor, AR8, DHTR, dihydrotestosterone receptor, HUMARA, HYSP1, KD, NR3C4, Nuclear receptor subfamily 3 group C member 4, SBMA, SMAX1, TFM

Gene Symbol

AR

Additional Androgen Receptor V7 Products

Product Documents for Androgen Receptor V7 Antibody (DHTR.V7/9394R) - Azide and BSA Free

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Androgen Receptor V7 Antibody (DHTR.V7/9394R) - Azide and BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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