Androgen Receptor V7 Antibody (DHTR.V7/9394R)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-23821

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-23821-100ug
NBP3-23821-20ug
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Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Kappa Clone # DHTR.V7/9394R

Concentration

0.2 mg/ml

View all Androgen Receptor V7 Antibodies »

Product Specifications

Immunogen

Recombinant fragment (around aa600-920) of human Androgen Receptor-protein (Androgen Receptor-V7 specific) (exact sequence is proprietary)

Localization

Nucleus.

Specificity

AR V7 belongs to the nuclear hormone receptor family. It contains the nuclear receptor DNA binding domain. Steroid hormone receptors are ligand-activated transcription factors that regulate the expression of eukaryotic genes affecting cell proliferation and differentiation in target tissues. The activity of transcription factors is regulated by binding co-activators and co-repressors. This target is a splice variant of the androgen receptor that lacks the C-terminal androgen-binding site. AR-V7 plays an important role in the occurrence, development and drug resistance of prostate cancer.

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG Kappa

Description

Store at 2 to 8C. Non-hazardous. No MSDS required.

Scientific Data Images for Androgen Receptor V7 Antibody (DHTR.V7/9394R)

Androgen Receptor V7 Antibody (DHTR.V7/9394R) Immunohistochemistry-Paraffin: Androgen Receptor V7 Antibody (DHTR.V7/9394R) [NBP3-23821] -

Immunohistochemistry-Paraffin: Androgen Receptor V7 Antibody (DHTR.V7/9394R) [NBP3-23821] -

Immunohistochemistry-Paraffin: Androgen Receptor V7 Antibody (DHTR.V7/9394R) [NBP3-23821] - Formalin-fixed, paraffin-embedded human prostate carcinoma stained with Androgen Receptor V7 Antibody (DHTR.V7/9394R). HIER: Tris/EDTA, pH9.0, 95°C/45min. 2°CAb: HRP-Poly:30min. DAB:5min.

Applications for Androgen Receptor V7 Antibody (DHTR.V7/9394R)

Application
Recommended Usage

Immunohistochemistry-Paraffin

1-2ug/ml
Application Notes
Immunohistochemistry-Paraffin: 1-2ug/ml for 30 minutes at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95C followed by cooling at RT for 20 minutes. Optimal dilution for a specific application should be determined.

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

10mM PBS with 0.05% BSA

Preservative

0.05% Sodium Azide

Concentration

0.2 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C.

Background: Androgen Receptor V7

Androgens have a broad range of effects on the appearance and maintenance of male secondary sexual characteristics. Like other members of the steroid superfamily, the androgen receptor (AR) consists of an amino terminal modulating domain, a central DNA binding domain, a hinge region and a carboxy terminal ligand binding domain. The androgen receptor (AR) is a 110 kDa androgen-dependent transcription factor that is a member of the steroid/nuclear receptor gene superfamily. The AR signaling pathway plays a key role in development and function of male reproductive organs, including the prostate and epididymis. AR also plays a role in nonreproductive organs, such as muscle, hair follicles, and brain. Abnormalities in the AR signaling pathway have been linked to a number of diseases, including prostate cancer, Kennedy's disease and male infertility. The PI3K/Akt signaling pathway plays an important role in regulating AR activity through phosphorylation of AR at Ser213/210 and Ser791/790. Growth factors or cytokines may induce phosphorylation of AR through the PI3K/Akt pathway. Activation of the PI3K/AKt pathway is thought to have a survival role in prostate cancer by protecting cells from apoptosis.

Alternate Names

AIS, androgen receptor, AR8, DHTR, dihydrotestosterone receptor, HUMARA, HYSP1, KD, NR3C4, Nuclear receptor subfamily 3 group C member 4, SBMA, SMAX1, TFM

Gene Symbol

AR

Additional Androgen Receptor V7 Products

Product Documents for Androgen Receptor V7 Antibody (DHTR.V7/9394R)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Androgen Receptor V7 Antibody (DHTR.V7/9394R)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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