Androgen R/NR3C4 Antibody (23GB2975)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-51071

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NBP3-51071-100ul
NBP3-51071-20ul
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Key Product Details

Species Reactivity

Human, Mouse

Applications

Western Blot, Immunocytochemistry/ Immunofluorescence, Knockdown Validated

Label

Unconjugated

Antibody Source

Monoclonal Rabbit IgG Clone # 23GB2975

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all Androgen R/NR3C4 Antibodies »

Product Specifications

Immunogen

A synthesized peptide derived from human Androgen R/NR3C4 (Uniprot: P10275)

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Androgen R/NR3C4 Antibody (23GB2975)

Androgen R/NR3C4 Antibody (23GB2975)

Immunocytochemistry/ Immunofluorescence: Androgen R/NR3C4 Antibody (23GB2975)[NBP3-51071] -

Immunocytochemical staining of C2C12 cells with Androgen R/NR3C4 (1:1,000). Nuclei were stained blue with DAPI; Androgen receptor was stained magenta with Alexa Fluor(R) 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Low. Scale bar, 20 um.
Androgen R/NR3C4 Antibody (23GB2975)

Western Blot: Androgen R/NR3C4 Antibody (23GB2975)[NBP3-51071] -

Western blotting analysis using Androgen R/NR3C4 antibody (1:5,000) and HRP-conjugated goat anti-rabbit secondary antibody (1:20,000) respectively. Image was developed using FeQ(TM) ECL Substrate Kit.
Androgen R/NR3C4 Antibody (23GB2975)

Western Blot: Androgen R/NR3C4 Antibody (23GB2975)[NBP3-51071] -

Western blotting analysis using Androgen R/NR3C4 antibody (1:5,000) and HRP-conjugated goat anti-rabbit secondary antibody (1:20,000) respectively. Image was developed using FeQ(TM) ECL Substrate Kit.

Applications for Androgen R/NR3C4 Antibody (23GB2975)

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

Optimal dilutions of this antibody should be experimentally determined.

Knockdown Validated

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS (pH 7.4), 50% glycerol

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: Androgen R/NR3C4

Androgens have a broad range of effects on the appearance and maintenance of male secondary sexual characteristics. Like other members of the steroid superfamily, the androgen receptor (AR) consists of an amino terminal modulating domain, a central DNA binding domain, a hinge region and a carboxy terminal ligand binding domain. The androgen receptor (AR) is a 110 kDa androgen-dependent transcription factor that is a member of the steroid/nuclear receptor gene superfamily. The AR signaling pathway plays a key role in development and function of male reproductive organs, including the prostate and epididymis. AR also plays a role in nonreproductive organs, such as muscle, hair follicles, and brain. Abnormalities in the AR signaling pathway have been linked to a number of diseases, including prostate cancer, Kennedy's disease and male infertility. The PI3K/Akt signaling pathway plays an important role in regulating AR activity through phosphorylation of AR at Ser213/210 and Ser791/790. Growth factors or cytokines may induce phosphorylation of AR through the PI3K/Akt pathway. Activation of the PI3K/AKt pathway is thought to have a survival role in prostate cancer by protecting cells from apoptosis.

Long Name

Androgen Receptor

Alternate Names

AIS, AndrogenR, AR, DHTR, NR3C4, SBMA, SMAX1

Gene Symbol

AR

Additional Androgen R/NR3C4 Products

Product Documents for Androgen R/NR3C4 Antibody (23GB2975)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Androgen R/NR3C4 Antibody (23GB2975)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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