ICI 118,551 hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 0821
Highly selective β2 inverse agonist
Key Product Details
Description
Highly selective β2 inverse agonist
Product Description
ICI 118,551 hydrochloride is a very selective β2 adrenergic inverse agonist (Ki values are 1.2, 120 and 257 nM for β2, β1 and β3 receptors respectively). Active in vivo.Licensing Information
Sold with the permission of AstraZeneca UK Ltd.Product Specifications
Molecular Weight
313.87
Formula
C17H27NO2.HCl
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
(±)-erythro-(S*,S*)-1-[2,3-(Dihydro-7-methyl-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanol hydrochloride
CAS Number
72795-01-8
PubChem ID
46704341
InChI Key
KBXMBGWSOLBOQM-MELYUZJYSA-N
SMILES
CC1=C(CCC2)C2=C(OC[C@@H](O)[C@H](C)NC(C)C)C=C1.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 3.14 | 10 | |
| DMSO | 3.14 | 10 |
Preparing Stock Solutions
for ICI 118,551 hydrochloride
The following data is based on the product molecular weight 313.87
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 31.86 mL | 159.30 mL | 318.60 mL |
| 0.5 mM | 6.37 mL | 31.86 mL | 63.72 mL |
| 1 mM | 3.19 mL | 15.93 mL | 31.86 mL |
| 5 mM | 0.64 mL | 3.19 mL | 6.37 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Bond Physiological effects of inverse agonists in transgenic mice with myocardial overexpression of the β2-adrenoceptor. Nature 1995 PMID: 7885448
- Ten Berge β2-but not β3-adrenoceptors mediate prejunctional inhibition of non-adrenergic non cholinergic contraction of guinea pig main bronchi. Eur.J.Pharmacol. 1995 PMID: 7796855
- Cook β-Adrenoceptor subtypes and the opening of plasmalemmal K+-channels in trachealis muscle: electrophysiological and mechanical studies in guinea-pig tissue. Br.J.Pharmacol. 1993 PMID: 8104643
- Strosberg and Pietri-Rouxel Function and regulation of the β3-adrenoceptor. TiPS 1996 PMID: 8979772
- Bilski The pharmacology of a β2-selective adrenoceptor antagonist (ICI-118,551). J.Cardiovasc.Pharmacol. 1983 PMID: 6191142
Product Specific Notices for ICI 118,551 hydrochloride
For research use only
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