(S)-4-Carboxyphenylglycine
Tocris Bioscience, part of Bio-Techne | Catalog # 0323
Competitive group I mGlu antagonist; also weak group II agonist
Key Product Details
Description
Competitive group I mGlu antagonist; also weak group II agonist
Alternative Names
(S)-4CPG
Product Description
(S)-4-Carboxyphenylglycine is a competitive group I metabotropic glutamate receptor antagonist, with selectivity for mGlu1a/1a over mGlu5a/5b.Product Specifications
Molecular Weight
195.17
Formula
C9H9NO4
Storage
Store at RT
Purity
≥98% (HPLC)
CAS Number
134052-73-6
PubChem ID
5311459
InChI Key
VTMJKPGFERYGJF-ZETCQYMHSA-N
SMILES
[H][C@@](N)(C(O)=O)C1=CC=C(C(O)=O)C=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| 1eq. NaOH | 19.52 | 100 with gentle warming |
Preparing Stock Solutions
for (S)-4-Carboxyphenylglycine
The following data is based on the product molecular weight 195.17
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 5.12 mL | 25.62 mL | 51.24 mL |
| 5 mM | 1.02 mL | 5.12 mL | 10.25 mL |
| 10 mM | 0.51 mL | 2.56 mL | 5.12 mL |
| 50 mM | 0.10 mL | 0.51 mL | 1.02 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Eaton Competitive antagonism at metabotropic glutamate receptors by (S)-4-carboxyphenylglycine (CPG) and (RS)-α-methyl-4-carboxyphenylglycine (MCPG). Eur.J.Pharmacol. 1993 PMID: 8381746
- Brabet Phenylglycine derivatives discriminate between mGluR1-and mGluR5-mediated responses. Neuropharmacology 1995 PMID: 8532171
- Doherty Antagonist activity of α-substituted 4-carboxyphenylglycine analogues at group I metabotropic glutamate receptors expressed in CHO cells. Br.J.Pharmacol. 1999 PMID: 10051137
- Birse Phenylglycine derivatives as new pharmacological tools for investigating the role of metabotropic glutamate receptors in the central nervous system. Neuroscience 1993 PMID: 7680790
Product Specific Notices for (S)-4-Carboxyphenylglycine
For research use only
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