USP18: Proteins and Enzymes

UBP43, also known as Ubiquitin Specific Peptidase 18 (USP18), is a member of the peptidase C19 family of deubiquitinating enzymes. It is a nuclear protein highly expressed in the liver, thymus, and peritoneal macrophages, as well as in monocyte-derived cell lines. UBP43/USP18 is 372 amino acids (aa) in length with a predicted molecular weight of 43 kDa. Human UBP43/USP18 shares 72% and 73% aa sequence identity with the mouse and rat orthologs, respectively. UBP43/USP18 is an ...