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2 results for "TrkB" in Products

TrkB Products

Members of the Trk family (TrkA, B, and C) of receptor tyrosine kinases act as receptors for the neurotrophin family: BDNF, NGF, NT-3, and NT-4. Trks exhibit selectivity for specific neurotrophins. TrkA, TrkB and TrkC preferentially bind NGF, NT-4 and BDNF, and NT-3, respectively. All Trk family proteins share a common structural organization consisting of an extracellular region with two cysteine-rich domains, a cluster of three leucine-rich motifs, and two immunoglobulin-like domains, and an intracellular region that contains the tyrosine kinase domain. They are best known for their regulation of neuronal survival and axon outgrowth.

Potent Trk inhibitor; inhibits TrkA, TrkB and TrkC

Chemical Name:
N-[3-[[2,3-Dihydro-2-oxo-3-(1H-pyrrol-2-ylmethylene)-1H-indol-6-yl]amino]-4-methylphenyl]-N'-[2-fluoro-5-(trifluoromethyl)phenyl]urea
Purity:
≥98%
Potent Trk inhibitor; inhibits TrkA, TrkB and TrkC

TrkB agonist

Alternate Names:
7,8-DHF
Chemical Name:
7,8-Dihydroxy-2-phenyl-4H-1-benzopyran-4-one
Purity:
≥98%
TrkB agonist
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