7,8-Dihydroxyflavone
Tocris Bioscience, part of Bio-Techne | Catalog # 3826
TrkB agonist
Key Product Details
Description
TrkB agonist
Alternative Names
7,8-DHF
Product Description
7,8-Dihydroxyflavone is a tyrosine kinase receptor B (TrkB) agonist that binds to the extracellular domain of the receptor (Kd = 320 nM). Inhibits glutamate-triggered apoptosis in hippocampal neurons in vitro and in vivo. Exhibits neuroprotective effects in an HD mouse model.Product Specifications
Molecular Weight
254.24
Formula
C15H10O4
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
7,8-Dihydroxy-2-phenyl-4H-1-benzopyran-4-one
CAS Number
38183-03-8
PubChem ID
1880
InChI Key
COCYGNDCWFKTMF-UHFFFAOYSA-N
SMILES
O=C2C1=CC=C(O)C(O)=C1OC(C3=CC=CC=C3)=C2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| 2eq. NaOH | 25.42 | 100 | |
| DMSO | 25.42 | 100 |
Preparing Stock Solutions
for 7,8-Dihydroxyflavone
The following data is based on the product molecular weight 254.24
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.93 mL | 19.67 mL | 39.33 mL |
| 5 mM | 0.79 mL | 3.93 mL | 7.87 mL |
| 10 mM | 0.39 mL | 1.97 mL | 3.93 mL |
| 50 mM | 0.08 mL | 0.39 mL | 0.79 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Andero 7,8-dihydroxyflavone, a TrkB receptor agonist, blocks long-term spatial memory impairment caused by immobilzation stress in rats. Hippocampus 2012 PMID: 21136519
- Jiang Small-molecule TrkB receptor agonists improve motor function and extend survival in a mouse model of Huntington's disease. Hum.Mol.Genet. 2013 PMID: 23446639
- Jang A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone. Proc.Natl.Acad.Sci.USA
Product Specific Notices for 7,8-Dihydroxyflavone
For research use only
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