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TRAILR1/TNFRSF10A Products

TNF-related apoptosis-inducing ligand (TRAIL), also known as Apo-2 ligand and TNFSF10, is a type II transmembrane protein with a carboxy-terminal extracellular domain that exhibits homology to other TNF superfamily members.

TRAIL binds at least five different receptors: TRAILR1 (DR4), R2 (DR5), R3 (DcR1), R4 (DcR2), and osteoprotegerin (OPG). TRAIL receptors all exhibit cysteine-rich repeats characteristic of the TNF receptor superfamily. TRAILR1 and R2 are type 1 transmembrane proteins with intracellular death domains (DD) and, subsequently, have the ability to mediate TRAIL-induced apoptosis. The remaining receptors are decoys that may regulate TRAIL activity by competing for binding sites with TRAILR1 and R2. TRAILR3 is membrane-associated via GPI linkage. TRAILR4 is a type 1 transmembrane receptor, but exhibits a truncated cytoplasmic domain. Like the active receptors TRAILR1 and R2, OPG has a DD motif but is a soluble protein.

18 results for "TRAILR1/TNFRSF10A" in Products

TRAILR1/TNFRSF10A Products

TNF-related apoptosis-inducing ligand (TRAIL), also known as Apo-2 ligand and TNFSF10, is a type II transmembrane protein with a carboxy-terminal extracellular domain that exhibits homology to other TNF superfamily members.

TRAIL binds at least five different receptors: TRAILR1 (DR4), R2 (DR5), R3 (DcR1), R4 (DcR2), and osteoprotegerin (OPG). TRAIL receptors all exhibit cysteine-rich repeats characteristic of the TNF receptor superfamily. TRAILR1 and R2 are type 1 transmembrane proteins with intracellular death domains (DD) and, subsequently, have the ability to mediate TRAIL-induced apoptosis. The remaining receptors are decoys that may regulate TRAIL activity by competing for binding sites with TRAILR1 and R2. TRAILR3 is membrane-associated via GPI linkage. TRAILR4 is a type 1 transmembrane receptor, but exhibits a truncated cytoplasmic domain. Like the active receptors TRAILR1 and R2, OPG has a DD motif but is a soluble protein.

18 results for "TRAILR1/TNFRSF10A" in Products

WB, IHC, Neut
Flow, IHC, CyTOF-ready
Catalog #: 6949-DR
BA
BA

A New rh TRAIL R1 is Now Available! ~2 fold better activity; CHO expressed; No his tag!

WB
Catalog #: FAB347S
Flow
Catalog #: FAB347N
Flow
Flow
Catalog #: FAB347V
Flow
Catalog #: FAB347G
Flow
Catalog #: FAB347U
Flow
Catalog #: FAB347T
Flow
Catalog #: FAB347R
Flow
Catalog #: RDC1426

Contains 4 membranes - each spotted in duplicate with 35 different apoptosis antibodies

Contains 4 membranes-each spotted in duplicate with 41 different proteins and 4 serine or tyrosine phosphorylation sites antibodies

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