5 results for "Tankyrase Inhibitors Small Molecules and Peptides" in Products
Tankyrase Inhibitors: Small Molecules and Peptides
The Tankyrases (TNKS1/PARP5A and TNKS2/PARP5B) are poly (ADP-ribose) polymerases that catalyze the ADP-ribosylation of target proteins. TNKS' are involved in the regulation of Wnt/β-catenin signaling and have been implicated in the pathology of various forms of cancer.
TNKS1 and TNKS2 consist of ankyrin repeats, a SAM domain, and a catalytic ARTD domain. Substrates bind to TNKS through the ankyrin repeats, whereas the SAM domain mediates TNKS multimerization. The ARTD domain catalyzes the ...
Potent tankyrase inhibitor
| Alternate Names: | XAV939 Wnt Signaling Inhibitor |
| Chemical Name: | 3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one |
| Purity: | ≥98% (HPLC) |
Potent tankyrase inhibitor
| Chemical Name: | 2-[3-[[4-(4-Methoxyphenyl)-5-(4-pyridinyl)-4H-1,2,4-triazol-3-yl]thio]propyl]-1H-benz[de]isoquinoline-1,3(2H)-dione |
| Purity: | ≥98% (HPLC) |
XAV 939 synthesized to cGMP guidelines
| Chemical Name: | 3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one |
| Purity: | ≥99% |
Tankyrase (AKA PARP5) inhibitor; used to generate neurons from epiblast stem cells
| Chemical Name: | N-(Cyclopropylmethyl)-4-(4-methoxybenzoyl)-N-[(3,5,7,8-tetrahydro-4-oxo-4H-pyrano[4,3-d]pyrimidin-2-yl)methyl]-1-piperidineacetamide |
| Purity: | ≥98% (HPLC) |
Potent TNKS1/2 inhibitor
| Chemical Name: | rel-2-[4-[6-[(3R,5S)-3,5-Dimethyl-1-piperazinyl]-4-methyl-3-pyridinyl]phenyl]-3,7-dihydro-7-methyl-4H-pyrrolo[2,3-d]pyrimidin-4-one |
| Purity: | ≥98% (HPLC) |
