WIKI4

Name: WIKI4
Brand: Tocris Bioscience
SKU: 4855

Tocris Bioscience a Bio-Techne Brand

Catalog # 4855

Citations (1)

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Key Product Details

Description:	Potent tankyrase inhibitor
Chemical Name:	2-[3-[[4-(4-Methoxyphenyl)-5-(4-pyridinyl)-4H-1,2,4-triazol-3-yl]thio]propyl]-1H-benz[de]isoquinoline-1,3(2H)-dione
Purity:	≥98% (HPLC)
Molecular Weight:	521.59

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Biological Activity for WIKI4

WIKI4 is an inhibitor of Wnt/β-catenin signaling (EC₅₀ ~ 75 nM). Inhibits auto-ADP-ribosylation of tankyrase 2 (TNKS2) (IC₅₀ ~15 nM); prevents the ubiquitination and degradation of axin. WIKI4 inhibits expression of β-catenin target genes in cancer cell lines as well as in human embryonic stem cells (ESC).

WIKI4 synthesized to Ancillary Material Grade also available.

Technical Data for WIKI4

M. Wt	521.59
Formula	C₂₉H₂₃N₅O₃S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	838818-26-1
PubChem ID	2984337
InChi Key	RNUXIZKXJOGYQP-UHFFFAOYSA-N
Smiles	O=C(C5=C4C(C6=O)=CC=CC4=CC=C5)N6CCCSC1=NN=C(C3=CC=NC=C3)N1C2=CC=C(OC)C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for WIKI4

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	5.22	10

Preparing Stock Solutions for WIKI4

The following data is based on the product molecular weight 521.59.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	19.17 mL	95.86 mL	191.72 mL
0.5 mM	3.83 mL	19.17 mL	38.34 mL
1 mM	1.92 mL	9.59 mL	19.17 mL
5 mM	0.38 mL	1.92 mL	3.83 mL

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References for WIKI4

References are publications that support the biological activity of the product.

James WIKI4, a novel inhibitor of tankyrase and Wnt/β-catenin signaling. PLoS One 2012 PMID: 23227175

Citations for WIKI4 (1)

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Citations are publications that use Bio-Techne products. Selected citations for WIKI4 include:

Yung et al. (2019) Sufu- And Spop-mediated downregulation of Hedgehog signaling promotes beta cell differentiation through organ-specific niche signals. Nat.Commun.. 10:4647
PMID: 31604927

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