SIRP gamma/CD172g: Proteins and Enzymes

Signal regulatory protein gamma (SIRP gamma, designated CD172g), also called SIRP beta 2, is a type I transmembrane protein belonging to the SIRP/SHPS (CD172) family within the Ig superfamily. SIRP gamma is expressed on T cells, CD56bright NK cells and activated NK cells, but not myeloid cells. Like SIRP alpha, it binds CD47, but unlike SIRP alpha, it does not contain an obvious signaling mechanism. T cell SIRP gamma may play a role as an accessory protein interacting with CD47-expressing antigen presenting cells, and appears to promote antigen-specific T cell proliferation and costimulate T cell activation.

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