RSK Inhibitors: Small Molecules and Peptides

Ribosomal S6 protein kinases (RSKs) are a family of protein serine/threonine kinases that regulate diverse cellular processes such as cell growth, motility, survival and proliferation. The RSK family can be divided into two subfamilies: p90 RSK and p70 S6K.

p90 RSKs phosphorylate numerous cytosolic and nuclear targets and act as downstream effectors of the ERK/MAPK signaling cascade. The four isoforms of this enzyme are expressed ubiquitously in human tissues and exist in multiple subcellular ...