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RIPK1/RIP1 Products
RIPK1 (Receptor (TNFRSF)-Interacting Serine-Threonine Kinase 1), also known as RIP1, contains an N-terminal protein kinase domain, a C-terminal death domain, and a unique internal region called the intermediate domain. It is a serine/threonine protein kinase and is constitutively expressed in many tissues. RIPK1 interacts with the cytoplasmic death domain of FAS and TNF receptors, and is an important element in apoptotic processes. RIPK1 has been shown to interact with a number of proteins including TRADD, TRAF1, TRAF2, and TRAF3, to form larger signaling complexes. These complexes, in turn, activate specific signaling cascades, such as NFkB.
6 results for "RIPK1/RIP1" in Products
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RIPK1/RIP1 Products
RIPK1 (Receptor (TNFRSF)-Interacting Serine-Threonine Kinase 1), also known as RIP1, contains an N-terminal protein kinase domain, a C-terminal death domain, and a unique internal region called the intermediate domain. It is a serine/threonine protein kinase and is constitutively expressed in many tissues. RIPK1 interacts with the cytoplasmic death domain of FAS and TNF receptors, and is an important element in apoptotic processes. RIPK1 has been shown to interact with a number of proteins including TRADD, TRAF1, TRAF2, and TRAF3, to form larger signaling complexes. These complexes, in turn, activate specific signaling cascades, such as NFkB.
6 results for "RIPK1/RIP1" in Products
| Clonality : | Monoclonal |
| Host : | Mouse IgG1 Clone #334640 |
| Applications : | Immunocytochemistry/Immunofluorescence, Knockout Validated, Simple Western, Western Blot |
Contains 4 membranes-each spotted in duplicate with 49 different antibodies to ubiquitin target proteins
RIP1 kinase inhibitor; inhibits necroptosis
| Chemical Name : | 5-(1H-Indol-3-ylmethyl)-3-methyl-2-thioxo-4-imidazolidinone |
| Purity : | ≥98% (HPLC) |
Necroptosis inhibitor; also inhibits pyroptosis
| Chemical Name : | (2E)-N-[4-[[(3-Methoxy-2-pyrazinyl)amino]sulfonyl]phenyl]-3-(5-nitro-2-thienyl)-2-propenamide |
| Purity : | ≥98% (HPLC) |
Potent and metabolically stable RIP1 kinase inhibitor
| Chemical Name : | N-Hydroxy-2,2-dimethyl-N-(phenylmethyl)butanamide |
| Purity : | ≥98% (HPLC) |
