Reelin: Proteins and Enzymes

Reelin is a 400 kDa modular glycoprotein that is critical in brain development and function. Reeler mutant mice have a Reelin deficiency and exhibit ataxia, tremors, and impaired motor coordination. Reelin consists of an N-terminal Reelin domain, eight domains that consist of an EGF-like repeat flanked by two subrepeats, and a C-terminal arginine-rich region. Reelin is cleaved into three fragments in vivo by metalloproteases. One (or central) fragment includes domains # 3 - 6 and retains many ...