Rap1A: Proteins and Enzymes

Ras-related Protein 1A (Rap1A) is a membrane-localized member of the Ras small GTPase superfamily of proteins. It is a 184 amino acid (aa) propeptide with a predicted molecular mass of 21 kDa. Bioactive Rap1A is processed into a 181 aa active form via the removal of aa 182-184. The rodent Rap1A orthologs share 100% aa identity with the human protein. The enzymatic activity of Rap1A is activated by EPAC and EPAC2, which are guanine nucleotide exchange factors (GEFs). Following activation, Rap1A ...