PSMA/FOLH1/NAALADase I Products
Human prostate-specific membrane antigen (PSMA), a tumor marker in prostate cancer encoded by the FOLH1 gene, is a type II transmembrane zinc metallopeptidase. PSMA is most highly expressed in the nervous system, prostate, kidney, and small intestine. The enzyme is also known as glutamate carboxypeptidase II (GCPII), folate hydrolase 1, folypoly-gamma-glutamate carboxypeptidase (FGCP), and N-acetylated-alpha-linked acidic dipeptidase I (NAALADase I).
In the brain, PSMA hydrolyzes the neurotransmitter N-acetyl-Asp-Glu to produce glutamate, another neurotransmitter. Inhibition of brain PSMA activity is considered to be a promising approach for the treatment of neurological disorders associated with glutamate excitotoxicity, such as stroke, chronic pain, and amyotrophic lateral sclerosis. Intestinal PSMA hydrolyzes folylpoly-gamma-glutamates, facilitating the uptake of folate.
557 results for "PSMA/FOLH1/NAALADase I" in Products
557 results for "PSMA/FOLH1/NAALADase I" in Products
PSMA/FOLH1/NAALADase I Products
Human prostate-specific membrane antigen (PSMA), a tumor marker in prostate cancer encoded by the FOLH1 gene, is a type II transmembrane zinc metallopeptidase. PSMA is most highly expressed in the nervous system, prostate, kidney, and small intestine. The enzyme is also known as glutamate carboxypeptidase II (GCPII), folate hydrolase 1, folypoly-gamma-glutamate carboxypeptidase (FGCP), and N-acetylated-alpha-linked acidic dipeptidase I (NAALADase I).
In the brain, PSMA hydrolyzes the neurotransmitter N-acetyl-Asp-Glu to produce glutamate, another neurotransmitter. Inhibition of brain PSMA activity is considered to be a promising approach for the treatment of neurological disorders associated with glutamate excitotoxicity, such as stroke, chronic pain, and amyotrophic lateral sclerosis. Intestinal PSMA hydrolyzes folylpoly-gamma-glutamates, facilitating the uptake of folate.
| Reactivity: | Human, Mouse, Rat, Canine, Porcine |
| Details: | Mouse IgG1 Monoclonal Clone #GCP-04 |
| Applications: | IHC, WB, ICC/IF |
![Western Blot: PSMA/FOLH1/NAALADase I Antibody (GCP-04)BSA Free [NBP1-45057]](https://resources.bio-techne.com/images/products/PSMA-FOLH1-NAALADase-I-Antibody-GCP-04-Western-Blot-NBP1-45057-img0011.jpg "Western Blot: PSMA/FOLH1/NAALADase I Antibody (GCP-04)BSA Free [NBP1-45057]")
| Reactivity: | Human, Canine, Feline, Equine |
| Details: | Mouse IgG2b Kappa Monoclonal Clone #FOLH1/2354 |
| Applications: | IHC, WB, MA |
![Western Blot: PSMA/FOLH1/NAALADase I Antibody (FOLH1/2354) [NBP3-07576]](https://resources.bio-techne.com/images/products/PSMA-FOLH1-NAALADase-I-Antibody-FOLH1-2354-Western-Blot-NBP3-07576-img0003.jpg "Western Blot: PSMA/FOLH1/NAALADase I Antibody (FOLH1/2354) [NBP3-07576]")
| Reactivity: | Human, Canine, Feline, Equine |
| Details: | Mouse IgG2b Kappa Monoclonal Clone #FOLH1/2354 |
| Applications: | IHC, WB, MA |
![Western Blot: PSMA/FOLH1/NAALADase I Antibody (FOLH1/2354)Azide and BSA Free [NBP3-08385]](https://resources.bio-techne.com/images/products/PSMA-FOLH1-NAALADase-I-Antibody-FOLH1-2354-Azide-and-BSA-Free-Western-Blot-NBP3-08385-img0002.jpg "Western Blot: PSMA/FOLH1/NAALADase I Antibody (FOLH1/2354)Azide and BSA Free [NBP3-08385]")
| Reactivity: | Human |
| Details: | Mouse IgG2b Kappa Monoclonal Clone #FOLH1/2121 |
| Applications: | ELISA |
| Reactivity: | Human |
| Details: | Rabbit IgG Monoclonal Clone #FOLH1/3149R |
| Applications: | IHC |
![Immunohistochemistry-Paraffin: PSMA/FOLH1/NAALADase I Antibody (FOLH1/3149R) [NBP3-07590]](https://resources.bio-techne.com/images/products/PSMA-FOLH1-NAALADase-I-Antibody-FOLH1-3149R-Immunohistochemistry-Paraffin-NBP3-07590-img0001.jpg "Immunohistochemistry-Paraffin: PSMA/FOLH1/NAALADase I Antibody (FOLH1/3149R) [NBP3-07590]")
| Reactivity: | Human |
| Details: | Rabbit IgG Monoclonal Clone #FOLH1/3149R |
| Applications: | IHC |
![Immunohistochemistry-Paraffin: PSMA/FOLH1/NAALADase I Antibody (FOLH1/3149R) - Azide and BSA Free [NBP3-08463]](https://resources.bio-techne.com/images/products/PSMA-FOLH1-NAALADase-I-Antibody-FOLH1-3149R-Azide-and-BSA-Free-Immunohistochemistry-Paraffin-NBP3-08463-img0001.jpg "Immunohistochemistry-Paraffin: PSMA/FOLH1/NAALADase I Antibody (FOLH1/3149R) - Azide and BSA Free [NBP3-08463]")
| Reactivity: | Human, Canine, Feline, Equine |
| Details: | Mouse IgG2b Kappa Monoclonal Clone #FOLH1/2354 |
| Applications: | IHC, WB, MA |
| Reactivity: | Human, Canine, Feline, Equine |
| Details: | Mouse IgG2b Kappa Monoclonal Clone #FOLH1/2354 |
| Applications: | IHC, WB, MA |
| Reactivity: | Human |
| Details: | Rabbit IgG Monoclonal Clone #FOLH1/3149R |
| Applications: | IHC |
![PSMA/FOLH1/NAALADase I Antibody (FOLH1/3149R) [CoraFluor™ 1]](https://resources.bio-techne.com/images/products/nbp3-08463cl1_rabbit-psma-folh1-naaladase-i-mab-folh1-3149r-cl1-12920251174423.png "Product Feature: CoraFluor Probes for TR-FRET")
| Reactivity: | Human |
| Details: | Mouse IgG2b Kappa Monoclonal Clone #FOLH1/2121 |
| Applications: | ELISA |
| Reactivity: | Human |
| Details: | Mouse IgG2b Kappa Monoclonal Clone #FOLH1/2121 |
| Applications: | ELISA |
| Reactivity: | Human |
| Details: | Mouse IgG2b Kappa Monoclonal Clone #FOLH1/2121 |
| Applications: | ELISA |
| Reactivity: | Human |
| Details: | Rabbit IgG Monoclonal Clone #FOLH1/3149R |
| Applications: | IHC |
| Reactivity: | Human |
| Details: | Rabbit IgG Monoclonal Clone #FOLH1/3149R |
| Applications: | IHC |
| Reactivity: | Human |
| Details: | Rabbit IgG Monoclonal Clone #FOLH1/3149R |
| Applications: | IHC |
| Reactivity: | Human |
| Details: | Mouse IgG2b Kappa Monoclonal Clone #FOLH1/2121 |
| Applications: | ELISA |
| Reactivity: | Human |
| Details: | Mouse IgG2b Kappa Monoclonal Clone #FOLH1/2121 |
| Applications: | ELISA |
| Reactivity: | Human |
| Details: | Mouse IgG2b Kappa Monoclonal Clone #FOLH1/2121 |
| Applications: | ELISA |
| Reactivity: | Human |
| Details: | Rabbit IgG Monoclonal Clone #FOLH1/3149R |
| Applications: | IHC |
| Reactivity: | Human |
| Details: | Rabbit IgG Monoclonal Clone #FOLH1/3149R |
| Applications: | IHC |
| Reactivity: | Human |
| Details: | Rabbit IgG Monoclonal Clone #FOLH1/3149R |
| Applications: | IHC |
| Reactivity: | Human, Canine, Feline, Equine |
| Details: | Mouse IgG2b Kappa Monoclonal Clone #FOLH1/2354 |
| Applications: | IHC, WB, MA |
| Reactivity: | Human |
| Details: | Mouse IgG2b Kappa Monoclonal Clone #FOLH1/2121 |
| Applications: | ELISA |
| Reactivity: | Human, Canine, Feline, Equine |
| Details: | Mouse IgG2b Kappa Monoclonal Clone #FOLH1/2354 |
| Applications: | IHC, WB, MA |
| Reactivity: | Human |
| Details: | Mouse IgG2b Kappa Monoclonal Clone #FOLH1/2121 |
| Applications: | ELISA |