NOV/CCN3: Proteins and Enzymes

NOV belongs to the CCN (CTGF/CYR61/NOV) family of secreted proteins that share a common multimodular organization. Each protein contains an IGFBP domain, a von Willebrand factor type C domain, a thrombospondin type I domain and a cysteine knot domain. NOV interacts with several proteins and is involved in both internal and external cell signaling.

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