Nope/IGDCC4: Proteins and Enzymes

Mouse Nope/IGDCC4 (Neighbor Of Punc E11) was discovered as a gene proximal to the Punc gene on chromosome 9. Punc and Nope/IGDCC4 are distant members of a subgroup of the immunoglobulin (Ig) superfamily. Nope shares structural similarities with the DCC family of Netrin receptors. Mouse Nope/IGDCC4 is expressed mostly in embryonic muscle tissues and in developing and adult nervous systems.