NK1 Receptor Antagonists: Small Molecules and Peptides
NK1R (Neurokinin-1 receptor), gene name TACR1 (tachykinin receptor-1), is a 100 kDa 7-transmembrane glycoprotein receptor for the proinflammatory tachykinin neuropeptide, substance P. NK1R is constitutively or inducibly expressed on a wide variety of cells, including monocytes, macrophages, microglia, lymphocytes, neutrophils, mast cells, and neurons.
13 results for "NK1 Receptor Antagonists Small Molecules and Peptides" in Products
13 results for "NK1 Receptor Antagonists Small Molecules and Peptides" in Products
NK1 Receptor Antagonists: Small Molecules and Peptides
NK1R (Neurokinin-1 receptor), gene name TACR1 (tachykinin receptor-1), is a 100 kDa 7-transmembrane glycoprotein receptor for the proinflammatory tachykinin neuropeptide, substance P. NK1R is constitutively or inducibly expressed on a wide variety of cells, including monocytes, macrophages, microglia, lymphocytes, neutrophils, mast cells, and neurons.
MRGPRX2 antagonist; also NK1 receptor antagonist
| Purity: | ≥90% (HPLC) |
Potent NK1 antagonist
| Chemical Name: | 1-[2-[(3S)-3-(3,4-Dichlorophenyl)-1-[2-[3-(1-methylethoxy)phenyl]acetyl]-3-piperidinyl]ethyl]-4-phenyl-1-azoniabicyclo[2.2.2]octane chloride |
| Purity: | ≥97% (HPLC) |
Potent long-acting hNK1 antagonist
| Chemical Name: | 5-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-3H-1,2,4-triazol-3-one |
| Purity: | ≥98% (HPLC) |
Potent NK1 antagonist
| Chemical Name: | (2S,3S)-3-[[3,5-bis(Trifluoromethyl)phenyl]methoxy]-2-phenylpiperidine hydrochloride |
| Purity: | ≥98% (HPLC) |
Positive allosteric modulator of mGlu7 and mGlu8 receptors; also NK1 antagonist; brain penetrant
| Chemical Name: | 3-(2,3-Difluoro-4-methoxyphenyl)-2,5-dimethyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine |
| Purity: | ≥98% (HPLC) |
Potent and selective NK1 antagonist
| Chemical Name: | (3aR,7aR)-Octahydro-2-[1-imino-2-(2-methoxyphenyl)ethyl]-7,7-diphenyl-4H-isoindol |
| Purity: | ≥97% (HPLC) |
High affinity NK1 antagonist
| Chemical Name: | 5-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl-N,N-dimethyl-1H-1,2,3-triazole-4-methanamine hydrochloride |
| Purity: | ≥98% (HPLC) |
Potent and selective NK1 antagonist
| Chemical Name: | (2S,3S)-N-(2-Methoxyphenyl)methyl-2-diphenylmethyl-1-azabicyclo[2.2.2]octan-3-amine |
| Purity: | ≥98% (HPLC) |
High affinity NK1 antagonist
| Chemical Name: | (4R)-4-Hydroxy-1-[(1-methyl-1H-indol-3-yl)carbonyl]-L-prolyl-N-methyl-3-(2-naphthalenyl)-N-(phenylmethyl)-L-alaninamide |
| Purity: | ≥98% (HPLC) |
Highly selective human NK1 antagonist
| Chemical Name: | 1-[[(2-Nitrophenyl)amino]carbonyl]-L-prolyl-N-methyl-3-(2-naphthalenyl)-N-(phenylmethyl)-L-alaninamide |
| Purity: | ≥98% (HPLC) |
Potent and selective NK1 antagonist
| Chemical Name: | (2S,3S)-N-[[2-Methoxy-5-(1H-tetrazol-1-yl)phenyl]methyl]-2-phenyl-3-piperidinamine dihydrochloride |
| Purity: | ≥98% (HPLC) |
High affinity NK1 antagonist
| Chemical Name: | (2S,3S)-N-[[2-Methoxy-5-(trifluoromethoxy)phenyl]methyl]-2-phenyl-3-piperidinamine dihydrochloride |
| Purity: | ≥98% (HPLC) |
High affinity NK1 antagonist
| Chemical Name: | (2S,3S)-N-[(2-Methoxyphenyl)methyl]-2-phenyl-3-piperidinamine dihydrochloride |
| Purity: | ≥98% (HPLC) |
