L 760735
Tocris Bioscience, part of Bio-Techne | Catalog # 4013
High affinity NK1 antagonist
Product Description
L 760735 is a high affinity NK1 receptor antagonist (IC50 = 0.19 nM at human NK1 receptors). Selective (>300-fold) over h-NK2 and h-NK3 receptors. Exhibits anxiolytic and antidepressant-like effects. Orally active.Product Specifications
Molecular Weight
611.98
Formula
C26H28F7N5O2.HCl
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
5-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl-N,N-dimethyl-1H-1,2,3-triazole-4-methanamine hydrochloride
CAS Number
188923-01-5
PubChem ID
9809076
InChI Key
VZBKOBSSEVXFNF-QIRDZIKRSA-N
SMILES
FC(C=C3)=CC=[C@@]3[C@@H]1N(CC4=C(CN(C)C)NN=N4)CCO[C@@H]1O[C@H](C)C2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 18.36 | 30 | |
| DMSO | 30.6 | 50 |
Preparing Stock Solutions
for L 760735
The following data is based on the product molecular weight 611.98
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 3.27 mL | 16.34 mL | 32.68 mL |
| 2.5 mM | 0.65 mL | 3.27 mL | 6.54 mL |
| 5 mM | 0.33 mL | 1.63 mL | 3.27 mL |
| 25 mM | 0.07 mL | 0.33 mL | 0.65 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Duffy Correlation of neurokinin (NK) 1 receptor occupancy in gerbil striatum with behavioral effects of NK1 antagonists. J.Pharmacol.Exp.Ther 2002 PMID: 11961054
- Harrison An orally active, water-soluble neurokinin-1 receptor antagonist suitable for both intravenous and oral clinical administration. J.Med.Chem. 2001 PMID: 11708932
Product Specific Notices for L 760735
For research use only
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