7 results for "MET Inhibitors Small Molecules and Peptides" in Products
MET Inhibitors: Small Molecules and Peptides
The MET receptor, also known as hepatocyte growth factor receptor (HGFR), is a proto-oncogenic receptor tyrosine kinase. The endogenous ligand for the MET receptor is hepatocyte growth factor/scatter factor (HGF), a disulfide-linked heterodimeric molecule produced predominantly by mesenchymal cells.
In the adult, MET receptor expression is limited to stem and progenitor cells and is necessary for wound healing and hepatocyte regeneration. In the embryo, MET receptors are expressed on cells of ...
Potent and selective MET inhibitor
| Chemical Name: | (2R)-1-[[5-[(Z)-[5-[[(2,6-Dichlorophenyl)methyl]sulfonyl]-1,2-dihydro-2-oxo-3H-indol-3-ylidene]methyl]-2,4-dimethyl-1H-pyrrol-3-yl]carbonyl]-2-(1-pyrrolidinylmethyl)pyrrolidine |
| Purity: | ≥98% (HPLC) |
Highly selective MET inhibitor
| Chemical Name: | 4-[1-(6-Quinolinylmethyl)-1H-1,2,3-triazolo[4,5-b]pyrazin-6-yl]-1H-pyrazole-1-ethanol mesylate |
| Purity: | ≥98% (HPLC) |
VEGFR inhibitor. Also inhibits KIT, RET, MET and FLT3
| Alternate Names: | Semaxinib |
| Chemical Name: | 3-[(3,5-Dimethyl-1H-pyrrol-2-yl)methylene]-1,3-dihydro-2H-indol-2-one |
| Purity: | ≥98% (HPLC) |
Potent c-MET/ALK inhibitor
| Alternate Names: | PF 02341066,PF 2341066 |
| Chemical Name: | 3-[(1R)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-2-pyridinamine |
| Purity: | ≥98% (HPLC) |
Selective and potent c-MET kinase inhibitor
| Chemical Name: | 6-[[6-(1-Methyl-1H-pyrazol-4-yl)-1,2,4-triazolo[4,3-b]pyridazin-3-yl]thio]quinoline |
| Purity: | ≥98% (HPLC) |
Protein kinase inhibitor
| Alternate Names: | SF 2370 |
| Chemical Name: | (9S,10R,12R)-2,3,9,10,11,12-Hexahydro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid methyl ester |
| Purity: | ≥98% (HPLC) |
Potent VEGFR inhibitor; also inhibits other RTKs
| Alternate Names: | Cabozantinib,BMS 907351 |
| Chemical Name: | N-[4-[(6,7-Dimethoxy-4-quinolinyl)oxy]phenyl]-N-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide |
| Purity: | ≥98% (HPLC) |
