210 results for "Mcl-1" in Products
Mcl-1 Products
Mcl-1 (Myeloid Cell Leukemia 1) is a member of the Bcl-2 family of proteins. Alternative splicing results in two distinct isoforms: Mcl-1L (long) enhances cell survival by inhibiting apoptosis, while Mcl-1S (short) promotes apoptosis. The elimination of Mcl-1L is an early and required step for DNA damage-induced apoptosis. Degradation of Mcl-1L is regulated by polyubiquitination, which targets Mcl-1L to the proteasome pathway.
| Applications: | PAGE, SPR |
![SDS-PAGE: Recombinant Human Mcl-1 His Protein [NBP2-51510]](https://resources.bio-techne.com/images/products/Recombinant-Human-Mcl-1-Protein-SDS-Page-NBP2-51510-img0001.jpg "SDS-PAGE: Recombinant Human Mcl-1 His Protein [NBP2-51510]")
Contains 8 membranes - each spotted in duplicate with 21 different apoptosis antibodies
| Source: | E. coli |
| Applications: | WB |
Potent and selective kinesin spindle protein (KSP) inhibitor; induces Mcl-1 degradation
| Alternate Names: | Filanesib |
| Chemical Name: | (2S)-2-(3-Aminopropyl)-5-(2,5-difluorophenyl)-N-methoxy-N-methyl-2-phenyl-1,3,4-thiadiazole-3(2H)-carboxamide trifluoroacetate |
| Purity: | ≥98% (HPLC) |
| Reactivity: | Human |
| Details: | Mouse IgG2b Monoclonal Clone #602901 |
| Applications: | IHC |
Catalog #:
FAB8281AFP680
| Reactivity: | Human |
| Details: | Mouse IgG2b Monoclonal Clone #602901 |
Catalog #:
FAB828AFP594
| Reactivity: | Human |
| Details: | Mouse IgG2b Monoclonal Clone #542808 |
| Reactivity: | Human |
| Details: | Mouse IgG2b Monoclonal Clone #542808 |
| Applications: | WB, IHC, KO |
Inhibitor of Bcl-2 family members; antiapoptotic
| Alternate Names: | GX15-070 |
| Chemical Name: | 2-[2-[(3,5-Dimethyl-1H-pyrrol-2-yl)methylene)-3-methoxy-2H-pyrrol-5-yl]-1H-indole methanesulfonate |
| Purity: | ≥98% (HPLC) |
| Reactivity: | Human |
| Details: | Sheep IgG Polyclonal |
| Applications: | WB, Simple Western, KO |
Catalog #:
FAB828G
| Reactivity: | Human |
| Details: | Mouse IgG2b Monoclonal Clone #542808 |
| Applications: | WB, IHC, KO |
Catalog #:
FAB828U
| Reactivity: | Human |
| Details: | Mouse IgG2b Monoclonal Clone #542808 |
| Applications: | WB, IHC, KO |
Catalog #:
FAB828X
| Reactivity: | Human |
| Details: | Mouse IgG2b Monoclonal Clone #542808 |
| Applications: | WB, IHC, KO |
Catalog #:
FAB828N
| Reactivity: | Human |
| Details: | Mouse IgG2b Monoclonal Clone #542808 |
| Applications: | WB, IHC, KO |
Catalog #:
FAB8281V
| Reactivity: | Human |
| Details: | Mouse IgG2b Monoclonal Clone #602901 |
| Applications: | IHC |
Catalog #:
AF8281T
| Reactivity: | Human |
| Details: | Sheep IgG Polyclonal |
| Applications: | WB, KO |
Catalog #:
AF8281N
| Reactivity: | Human |
| Details: | Sheep IgG Polyclonal |
| Applications: | WB, KO |
Catalog #:
FAB8281N
| Reactivity: | Human |
| Details: | Mouse IgG2b Monoclonal Clone #602901 |
| Applications: | IHC |
Catalog #:
AF8281G
| Reactivity: | Human |
| Details: | Sheep IgG Polyclonal |
| Applications: | WB, KO |
Catalog #:
AF8281V
| Reactivity: | Human |
| Details: | Sheep IgG Polyclonal |
| Applications: | WB, KO |
Catalog #:
FAB8281X
| Reactivity: | Human |
| Details: | Mouse IgG2b Monoclonal Clone #602901 |
| Applications: | IHC |
Catalog #:
AF8281R
| Reactivity: | Human |
| Details: | Sheep IgG Polyclonal |
| Applications: | WB, KO |
Catalog #:
AF8281U
| Reactivity: | Human |
| Details: | Sheep IgG Polyclonal |
| Applications: | WB, KO |
Catalog #:
FAB8281S
| Reactivity: | Human |
| Details: | Mouse IgG2b Monoclonal Clone #602901 |
| Applications: | IHC |