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MAP3K8/Tpl2/COT Products
MAP3K8, also called Tpl2 (tumor progression locus 2) or COT (Cancer Osaka Thyroid oncogene), is a cytosolic Ser/Thr kinase. MAP3K8 is one of the MAP kinase kinase (MAPKK) kinases that regulates the ERK1/ERK2 pathway in response to IL-1, facilitating IL-8 and MIP-1 beta production. MAP3K8 activates I kappa B kinases and induces the nuclear production of NF-kappa B.
4 results for "MAP3K8/Tpl2/COT" in Products
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MAP3K8/Tpl2/COT Products
MAP3K8, also called Tpl2 (tumor progression locus 2) or COT (Cancer Osaka Thyroid oncogene), is a cytosolic Ser/Thr kinase. MAP3K8 is one of the MAP kinase kinase (MAPKK) kinases that regulates the ERK1/ERK2 pathway in response to IL-1, facilitating IL-8 and MIP-1 beta production. MAP3K8 activates I kappa B kinases and induces the nuclear production of NF-kappa B.
4 results for "MAP3K8/Tpl2/COT" in Products
| Source : | Sf 9 (baculovirus) |
| Accession # : | NM_005204 |
| Applications : | Bioactivity |
| Clonality : | Monoclonal |
| Host : | Mouse IgG2b Clone #634130 |
| Applications : | Western Blot |
Potent and selective Tpl2 (Cot; MAP3K8) inhibitor
| Chemical Name : | 4-[(3-Chloro-4-fluorophenyl)amino]-6-[(3-pyridinylmethyl)amino]-1,7-naphthyridine-3-carbonitrile |
| Purity : | ≥99% (HPLC) |
Potent and selective Tpl2 (MAP3K8) inhibitor
| Chemical Name : | 8-Chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[[[1-(1-ethyl-4-piperidinyl)-1H-1,2,3-triazol-4-yl]methyl]amino]-3-quinolinecarbonitrile |
| Purity : | ≥98% (HPLC) |
