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LAP (TGF-beta 1) Products
TGF-beta 1 is expressed as a proprotein that is cleaved within the trans-Golgi to yield a latency-associated peptide (LAP) and the mature TGF-beta 1. Disulfide-linked homodimers of LAP and TGF-beta 1 remain noncovalently associated after secretion, forming the small latent TGF-beta 1 complex. Purified LAP can also associate with active TGF-beta and neutralize TGF-beta activity. Covalent linkage of LAP to one of three latent TGF-beta binding proteins (LTBPs) creates a large latent complex that can interact with the extracellular matrix. TGF-beta activation from latency is controlled by multiple factors including Plasmin, MMP-9, Thrombospondin-1, and various Integrins. The TGF-beta 1 LAP is capable of complexing with and inactivating all other human TGF-beta isoforms and those of most other species.
38 results for "LAP (TGF-beta 1)" in Products
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LAP (TGF-beta 1) Products
TGF-beta 1 is expressed as a proprotein that is cleaved within the trans-Golgi to yield a latency-associated peptide (LAP) and the mature TGF-beta 1. Disulfide-linked homodimers of LAP and TGF-beta 1 remain noncovalently associated after secretion, forming the small latent TGF-beta 1 complex. Purified LAP can also associate with active TGF-beta and neutralize TGF-beta activity. Covalent linkage of LAP to one of three latent TGF-beta binding proteins (LTBPs) creates a large latent complex that can interact with the extracellular matrix. TGF-beta activation from latency is controlled by multiple factors including Plasmin, MMP-9, Thrombospondin-1, and various Integrins. The TGF-beta 1 LAP is capable of complexing with and inactivating all other human TGF-beta isoforms and those of most other species.
38 results for "LAP (TGF-beta 1)" in Products
BA
| Source : | Sf 21 (baculovirus) |
| Accession # : | P01137.2 |
| Applications : | Bioactivity |
ICC, Neut
| Clonality : | Monoclonal |
| Host : | Mouse IgG1 Clone #27235 |
| Applications : | Block/Neutralize, Immunocytochemistry/Immunofluorescence |
Catalog #:
ARY024
Contains 4 membranes-each spotted in duplicate with 58 different obesity-related antibodies
Catalog #:
IC77541R
ICFlow
| Clonality : | Monoclonal |
| Host : | Mouse IgG2b Clone #1015022 |
| Applications : | Flow Cytometry |
ELISA
| Sensitivity : | 3.4 pg/mL |
| Assay Range : | 23.4 - 1,500 pg/mL (Cell Culture Supernates, Cell Lysates, Serum, Platelet-poor EDTA Plasma, Platelet-poor Heparin Plasma, Urine) |
| Applications : | ELISA |
Catalog #:
DY246
ELISA
| Assay Range : | 62.5 - 4,000 pg/mL |
| Applications : | ELISA |
Flow, CyTOF-ready
| Clonality : | Monoclonal |
| Host : | Mouse IgG1 Clone #27232 |
| Applications : | CyTOF-ready, Flow Cytometry |
WB, Simple Western, ICC, Neut
| Clonality : | Polyclonal |
| Host : | Goat IgG |
| Applications : | Block/Neutralize, Immunocytochemistry/Immunofluorescence, Simple Western, Western Blot |
Catalog #:
FAB7666G
Flow
| Clonality : | Monoclonal |
| Host : | Rat IgG2a Clone #860206 |
| Applications : | Flow Cytometry |
Flow, CyTOF-ready
| Clonality : | Monoclonal |
| Host : | Rat IgG2a Clone #860206 |
| Applications : | CyTOF-ready, Flow Cytometry |
Flow
| Clonality : | Monoclonal |
| Host : | Mouse IgG1 Clone #27232 |
| Applications : | Flow Cytometry |
Catalog #:
MAB77541
ELISA, CyTOF-ready, ICC, ICFlow
| Clonality : | Monoclonal |
| Host : | Mouse IgG2b Clone #1015022 |
| Applications : | CyTOF-ready, ELISA, Flow Cytometry, Immunocytochemistry/Immunofluorescence |
Catalog #:
MAB2461
| Clonality : | Monoclonal |
| Host : | Mouse IgG1 Clone #9005 |
| Applications : | ELISA Capture |
| Clonality : | Monoclonal |
| Host : | Mouse IgG2a Clone #27240 |
| Applications : | ELISA Detection |
Catalog #:
BAF246
WB
| Clonality : | Polyclonal |
| Host : | Goat IgG |
| Applications : | Western Blot |
WB, IHC, ICC, Neut
| Clonality : | Polyclonal |
| Host : | Goat IgG |
| Applications : | Block/Neutralize, Immunocytochemistry/Immunofluorescence, Immunohistochemistry, Western Blot |
Catalog #:
FAB7666T
Flow
| Clonality : | Monoclonal |
| Host : | Rat IgG2a Clone #860206 |
| Applications : | Flow Cytometry |
Catalog #:
FAB7666V
Flow
| Clonality : | Monoclonal |
| Host : | Rat IgG2a Clone #860206 |
| Applications : | Flow Cytometry |
Catalog #:
FAB7666N
Flow
| Clonality : | Monoclonal |
| Host : | Rat IgG2a Clone #860206 |
| Applications : | Flow Cytometry |
Catalog #:
FAB7666R
Flow
| Clonality : | Monoclonal |
| Host : | Rat IgG2a Clone #860206 |
| Applications : | Flow Cytometry |
Catalog #:
FAB7666U
Flow
| Clonality : | Monoclonal |
| Host : | Rat IgG2a Clone #860206 |
| Applications : | Flow Cytometry |
Catalog #:
FAB8118A
Flow
| Clonality : | Monoclonal |
| Host : | Rat IgG2a Clone #860206 |
| Applications : | Flow Cytometry |
Flow
| Clonality : | Monoclonal |
| Host : | Mouse IgG1 Clone #27232 |
| Applications : | Flow Cytometry |
Flow, ICC
| Clonality : | Monoclonal |
| Host : | Mouse IgG1 Clone #27232 |
| Applications : | Flow Cytometry, Immunocytochemistry/Immunofluorescence |
Catalog #:
FAB7666S
Flow
| Clonality : | Monoclonal |
| Host : | Rat IgG2a Clone #860206 |
| Applications : | Flow Cytometry |
