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LAP (TGF-beta 1) Products

TGF-beta 1 is expressed as a proprotein. It is cleaved within the trans-Golgi to yield a latency-associated peptide (LAP) and the mature TGF-beta 1. Disulfide-linked homodimers of LAP and TGF-beta 1 remain noncovalently associated after secretion, forming the small latent TGF-beta 1 complex. Purified LAP can also associate with active TGF-beta and neutralize TGF-beta activity.

Covalent linkage of LAP to one of three latent TGF-beta binding proteins (LTBPs) creates a large latent complex that can interact with the extracellular matrix. TGF-beta activation from latency is controlled by multiple factors including Plasmin, MMP-9, Thrombospondin-1, and various Integrins. The TGF-beta 1 LAP is capable of complexing with and inactivating all other human TGF-beta isoforms and those of most other species.

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133 results for "LAP (TGF-beta 1)" in Products

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LAP (TGF-beta 1) Products

TGF-beta 1 is expressed as a proprotein. It is cleaved within the trans-Golgi to yield a latency-associated peptide (LAP) and the mature TGF-beta 1. Disulfide-linked homodimers of LAP and TGF-beta 1 remain noncovalently associated after secretion, forming the small latent TGF-beta 1 complex. Purified LAP can also associate with active TGF-beta and neutralize TGF-beta activity.

Covalent linkage of LAP to one of three latent TGF-beta binding proteins (LTBPs) creates a large latent complex that can interact with the extracellular matrix. TGF-beta activation from latency is controlled by multiple factors including Plasmin, MMP-9, Thrombospondin-1, and various Integrins. The TGF-beta 1 LAP is capable of complexing with and inactivating all other human TGF-beta isoforms and those of most other species.

Products:

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133 results for "LAP (TGF-beta 1)" in Products

Catalog #: QC110
ELISA, Ctrl

For use with catalog number DLAP00

WB, Simple Western, ICC, Neut
ELISA, Flow, IHC, WB
WB, IHC, ICC, Neut
ICC, Neut
Flow, CyTOF-ready
Flow, CyTOF-ready
Catalog #: FAB7666U
Flow
Catalog #: FAB2463S
Flow
ELISA
ELISA, CyTOF-ready, ICC, ICFlow
Catalog #: FAB7666N
Flow
Catalog #: IC77541T
ICFlow
Catalog #: IC77541R
ICFlow
Catalog #: FAB7666T
Flow
Catalog #: FAB7666G
Flow
Catalog #: FAB7666V
Flow
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