Langerin/CD207: Proteins and Enzymes

Langerin (CD207) is a type II transmembrane glycoprotein which is member K of the C-type lectin domain family 4. Langerin is used as a marker for Langerhans cells (LCs) which represent the immature dendritic cells in the epidermis. LCs uniquely contain tennis racket-shaped endosomal recycling compartment subdomains with pentalamellar membranes termed Birbeck granules. Langerin is necessary and sufficient for Birbeck granule formation.

Langerin also mediates endocytosis of non-peptide antigens ...