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6 results for "Kinesin Inhibitors" in Products

Kinesin Inhibitors Products

Kinesin superfamily proteins (KIFs) are motor proteins that convert chemical energy, typically in the form of ATP, into mechanical force. They act upon microtubules to move vesicles and organelles within cells, cause the beating of flagella and cilia, and act within the mitotic and meiotic spindles to segregate replicated chromosomes to progeny cells.

Generally, kinesins mediate plus-end transport. Kinesins exist as dimers, with a catalytic 'head' domain and a 'stalk/tail' domain ...

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Potent kinesin spindle protein (KSP) inhibitor

Chemical Name: N-(3-Aminopropyl)-N-[(1R)-1-[7-chloro-4-oxo-3-(phenylmethyl)-4H-1-benzopyran-2-yl]-2-methylpropyl]-4-methylbenzamide hydrochloride
Purity: ≥98% (HPLC)
Potent kinesin spindle protein (KSP) inhibitor

Selective inhibitor of mitotic kinesin Eg5

Chemical Name: 1,2,3,4-Tetrahydro-4-(3-hydroxyphenyl)-6-methyl-2-thioxo-5-pyrimidinecarboxylic acid, ethyl ester
Purity: ≥98% (HPLC)
Selective inhibitor of mitotic kinesin Eg5

Kinesin-1 modulator; cell permeable

Chemical Name: 3,5-Dibromo-N'-((2,5-dimethyl-1-(3-nitrophenyl)-1H-pyrrol-3-yl)methylene)-4-hydroxybenzohydrazide
Purity: ≥98% (HPLC)
Kinesin-1 modulator; cell permeable

Potent and selective kinesin spindle protein (KSP) inhibitor; induces Mcl-1 degradation

Alternate Names: Filanesib
Chemical Name: (2S)-2-(3-Aminopropyl)-5-(2,5-difluorophenyl)-N-methoxy-N-methyl-2-phenyl-1,3,4-thiadiazole-3(2H)-carboxamide trifluoroacetate
Purity: ≥98% (HPLC)
Potent and selective kinesin spindle protein (KSP) inhibitor; induces Mcl-1 degradation

High affinity and selective allosteric KSP inhibitor

Alternate Names: SB 715992
Chemical Name: N-(3-Aminopropyl)-N-[(1R)-1-[7-chloro-3,4-dihydro-4-oxo-3-(phenylmethyl)-2-quinazolinyl]-2-methylpropyl]-4-methylbenzamide
Purity: ≥98% (HPLC)
High affinity and selective allosteric KSP inhibitor

Selective and ATP-competitive Kif18A inhibitor

Chemical Name: 4-Chloro-2-nitro-1-(phenylsulfonyl)benzene
Purity: ≥98% (HPLC)
Selective and ATP-competitive Kif18A inhibitor
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