Integrin alpha 4 beta 7/LPAM-1 Products
Integrin alpha 4 beta 7 (LPAM-1) is an integrin family adhesion receptor that shares subunits with VLA4 and the E-cadherin receptor. It is the non-covalent heterodimer of alpha 4/CD49d and beta 7 transmembrane subunits. Motifs within a4b7 bind to metal ions and regulate cell adhesion functions. a4b7 binds the mucosal addressin MAdCAM-1, as well as VCAM-1 and Fibronectin.
The chemokine receptor CCR9 and a4b7, both critical for homing to the intestinal mucosa, are induced during T cell activation in Peyer’s patches or mesenteric lymph nodes. a4b7-expressing Treg, memory T cells, and B cells home to the intestinal mucosa or the peritoneum. The HIV-1 envelope protein gp120 binds to the active form of a4b7 and may concentrate the virus in gut-associated lymphoid tissue (GALT).
Products:
293 results for "Integrin alpha 4 beta 7/LPAM-1" in Products
293 results for "Integrin alpha 4 beta 7/LPAM-1" in Products
Integrin alpha 4 beta 7/LPAM-1 Products
Integrin alpha 4 beta 7 (LPAM-1) is an integrin family adhesion receptor that shares subunits with VLA4 and the E-cadherin receptor. It is the non-covalent heterodimer of alpha 4/CD49d and beta 7 transmembrane subunits. Motifs within a4b7 bind to metal ions and regulate cell adhesion functions. a4b7 binds the mucosal addressin MAdCAM-1, as well as VCAM-1 and Fibronectin.
The chemokine receptor CCR9 and a4b7, both critical for homing to the intestinal mucosa, are induced during T cell activation in Peyer’s patches or mesenteric lymph nodes. a4b7-expressing Treg, memory T cells, and B cells home to the intestinal mucosa or the peritoneum. The HIV-1 envelope protein gp120 binds to the active form of a4b7 and may concentrate the virus in gut-associated lymphoid tissue (GALT).
Products:
| Source: | CHO |
| Accession #: | P13612 (Integrin a4); P26010 (Integrin beta 7) |
| Applications: | BA |
| Source: | HEK293 |
| Accession #: | P13612.3 (Integrin alpha 4) & P26010.1 (Integrin b |
| Applications: | BA |
| Source: | CHO |
| Accession #: | AAH68313 (Integrin alpha 4) & P26011 (Integrin beta 7) |
| Applications: | BA |
| Reactivity: | Human |
| Details: | Human IgG1 Monoclonal Clone #Hu143 |
| Applications: | Flow |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #CL11293 |
| Applications: | WB |
![Integrin alpha 4 beta 7/LPAM-1 Antibody (CL11293) - Azide and BSA Free Western Blot: Integrin alpha 4 beta 7/LPAM-1 Antibody [NBP3-44276]](https://resources.bio-techne.com/images/products/nbp3-44276_mouse-integrin-alpha-4-beta-7-mab-cl11293-azide-bsa-free-28220251337887.jpg "Western Blot: Integrin alpha 4 beta 7/LPAM-1 Antibody [NBP3-44276]")
| Reactivity: | Mouse |
| Details: | Rat IgG2a Kappa Monoclonal Clone #DATK32 |
| Applications: | IHC, Flow, IP, Func |
![Flow Cytometry: Integrin alpha 4 beta 7/LPAM-1 Antibody (DATK32) - Azide and BSA Free [NBP3-07899]](https://resources.bio-techne.com/images/products/Integrin-alpha-4-beta-7-LPAM-1-Antibody-DATK32-Azide-and-BSA-Free-Flow-Cytometry-NBP3-07899-img0002.jpg "Flow Cytometry: Integrin alpha 4 beta 7/LPAM-1 Antibody (DATK32) - Azide and BSA Free [NBP3-07899]")
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #CL11293 |
| Applications: | WB |
![Western Blot: Integrin alpha 4 beta 7/LPAM-1 Antibody [NBP3-21189] -](https://resources.bio-techne.com/images/products/nbp3-21189_mouse-integrin-alpha-4-beta-7-lpam-1-mab-cl11293-45202315502310.jpg "Western Blot: Integrin alpha 4 beta 7/LPAM-1 Antibody [NBP3-21189] -")
| Reactivity: | Mouse |
| Details: | Rat IgG2a Kappa Monoclonal Clone #DATK32 |
| Applications: | Flow |
![Flow Cytometry: Integrin alpha 4 beta 7/LPAM-1 Antibody (DATK32) - BSA Free [NBP1-43283]](https://resources.bio-techne.com/images/products/Integrin-alpha-4-beta-7-LPAM-1-Antibody-DATK32-Flow-Cytometry-NBP1-43283-img0004.jpg "Flow Cytometry: Integrin alpha 4 beta 7/LPAM-1 Antibody (DATK32) - BSA Free [NBP1-43283]")
| Reactivity: | Human |
| Details: | Human IgG1 Monoclonal Clone #Hu117 |
| Applications: | Flow, CyTOF-ready |
| Reactivity: | Human |
| Details: | Human IgG1 Monoclonal Clone #Hu117 |
| Applications: | Flow, CyTOF-ready |
Integrin alpha 4 beta 7/LPAM-1 Antibody [Janelia Fluor® 669] - (Research Grade vedolizumab Biosimilar)
| Reactivity: | Human |
| Details: | Human IgG1 Monoclonal |
| Applications: | ELISA, Flow, Func |
Integrin alpha 4 beta 7/LPAM-1 Antibody [CoraFluor™ 1] - (Research Grade abrilumab Biosimilar)
| Reactivity: | Human |
| Details: | Human IgG2 Monoclonal |
| Applications: | ELISA, Flow, Func |
Integrin alpha 4 beta 7/LPAM-1 Antibody [Janelia Fluor® 669] - (Research Grade etrolizumab Biosimilar)
| Reactivity: | Human |
| Details: | Human IgG1 Monoclonal |
| Applications: | ELISA, Flow, Func |
Integrin alpha 4 beta 7/LPAM-1 Antibody [Janelia Fluor® 525] - (Research Grade abrilumab Biosimilar)
| Reactivity: | Human |
| Details: | Human IgG2 Monoclonal |
| Applications: | ELISA, Flow, Func |
| Reactivity: | Human |
| Details: | Human IgG1 Monoclonal Clone #Hu143 |
| Applications: | Flow, CyTOF-ready |
![Integrin alpha 4 beta 7/LPAM-1 Antibody (Hu143) [CoraFluor™ 1]](https://resources.bio-techne.com/images/products/fab10548cl1_human-integrin-alpha-4-beta-7-lpam-1-mab-hu143-cl1-269202517233122.png "Product Feature: CoraFluor Probes for TR-FRET")
| Reactivity: | Human |
| Details: | Human IgG1 Monoclonal Clone #Hu117 |
| Applications: | Flow, CyTOF-ready |
![Integrin alpha 4 beta 7/LPAM-1 Antibody (Hu117) [CoraFluor™ 1]](https://resources.bio-techne.com/images/products/fab10078cl1_human-integrin-alpha-4-beta-7-lpam-1-mab-hu117-cl1-24920251647363.png "Product Feature: CoraFluor Probes for TR-FRET")
Integrin alpha 4 beta 7/LPAM-1 Antibody [CoraFluor™ 1] - (Research Grade etrolizumab Biosimilar)
| Reactivity: | Human |
| Details: | Human IgG1 Monoclonal |
| Applications: | ELISA, Flow, Func |
Integrin alpha 4 beta 7/LPAM-1 Antibody [CoraFluor™ 1] - (Research Grade vedolizumab Biosimilar)
| Reactivity: | Human |
| Details: | Human IgG1 Monoclonal |
| Applications: | ELISA, Flow, Func |
Integrin alpha 4 beta 7/LPAM-1 Antibody [Janelia Fluor® 525] - (Research Grade etrolizumab Biosimilar)
| Reactivity: | Human |
| Details: | Human IgG1 Monoclonal |
| Applications: | ELISA, Flow, Func |
| Reactivity: | Human |
| Details: | Human IgG1 Monoclonal Clone #Hu143 |
| Applications: | Flow, CyTOF-ready |
| Reactivity: | Human |
| Details: | Human IgG1 Monoclonal Clone #Hu143 |
| Applications: | Flow, CyTOF-ready |
Integrin alpha 4 beta 7/LPAM-1 Antibody [Janelia Fluor® 525] - (Research Grade vedolizumab Biosimilar)
| Reactivity: | Human |
| Details: | Human IgG1 Monoclonal |
| Applications: | ELISA, Flow, Func |
Integrin alpha 4 beta 7/LPAM-1 Antibody [Janelia Fluor® 669] - (Research Grade abrilumab Biosimilar)
| Reactivity: | Human |
| Details: | Human IgG2 Monoclonal |
| Applications: | ELISA, Flow, Func |
| Reactivity: | Mouse |
| Details: | Rat IgG2a Kappa Monoclonal Clone #DATK32 |
| Applications: | IHC, Flow, IP, Func |
| Reactivity: | Mouse |
| Details: | Rat IgG2a Kappa Monoclonal Clone #DATK32 |
| Applications: | IHC, Flow, IP, Func |