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Integrin alpha 4 beta 7/LPAM-1 Products
Integrin alpha 4 beta 7 (LPAM-1) is an integrin family adhesion receptor that shares subunits with VLA4 and the E-cadherin receptor. It is the non-covalent heterodimer of alpha 4/CD49d and beta 7 transmembrane subunits. Motifs within a4b7 bind to metal ions and regulate cell adhesion functions. a4b7 binds the mucosal addressin MAdCAM-1, as well as VCAM-1 and Fibronectin. The chemokine receptor CCR9 and a4b7, both critical for homing to intestinal mucosa, are induced during T cell activation in Peyer’s patches or mesenteric lymph nodes. a4b7-expressing Treg, memory T cells, and B cells home to the intestinal mucosa or the peritoneum. The HIV-1 envelope protein gp120 binds to the active form of a4b7 and may concentrate the virus in gut-associated lymphoid tissue (GALT).
26 results for "Integrin alpha 4 beta 7/LPAM-1" in Products
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Integrin alpha 4 beta 7/LPAM-1 Products
Integrin alpha 4 beta 7 (LPAM-1) is an integrin family adhesion receptor that shares subunits with VLA4 and the E-cadherin receptor. It is the non-covalent heterodimer of alpha 4/CD49d and beta 7 transmembrane subunits. Motifs within a4b7 bind to metal ions and regulate cell adhesion functions. a4b7 binds the mucosal addressin MAdCAM-1, as well as VCAM-1 and Fibronectin. The chemokine receptor CCR9 and a4b7, both critical for homing to intestinal mucosa, are induced during T cell activation in Peyer’s patches or mesenteric lymph nodes. a4b7-expressing Treg, memory T cells, and B cells home to the intestinal mucosa or the peritoneum. The HIV-1 envelope protein gp120 binds to the active form of a4b7 and may concentrate the virus in gut-associated lymphoid tissue (GALT).
26 results for "Integrin alpha 4 beta 7/LPAM-1" in Products
| Source : | CHO |
| Accession # : | P13612 (Integrin a4); P26010 (Integrin beta 7) |
| Applications : | Bioactivity |
| Source : | CHO |
| Accession # : | AAH68313 (Integrin alpha 4) & P26011 (Integrin beta 7) |
| Applications : | Bioactivity |
Recombinant Monoclonal Antibody For Research Use Only
| Clonality : | Monoclonal |
| Host : | Human IgG1 Clone #Hu143 |
| Applications : | Flow Cytometry |
Recombinant Monoclonal Antibody For Research Use Only
| Clonality : | Monoclonal |
| Host : | Human IgG1 Clone #Hu117 |
| Applications : | Flow Cytometry |
Recombinant Monoclonal Antibody For Research Use Only
| Clonality : | Monoclonal |
| Host : | Human IgG1 Clone #Hu117 |
| Applications : | Flow Cytometry |
Recombinant Monoclonal Antibody For Research Use Only
| Clonality : | Monoclonal |
| Host : | Human IgG1 Clone #Hu117 |
| Applications : | CyTOF-ready, Flow Cytometry |
Recombinant Monoclonal Antibody For Research Use Only
| Clonality : | Monoclonal |
| Host : | Human IgG1 Clone #Hu143 |
| Applications : | CyTOF-ready, Flow Cytometry |
Recombinant Monoclonal Antibody For Research Use Only
| Clonality : | Monoclonal |
| Host : | Human IgG1 Clone #Hu117 |
| Applications : | Flow Cytometry |
Recombinant Monoclonal Antibody For Research Use Only
| Clonality : | Monoclonal |
| Host : | Human IgG1 Clone #Hu143 |
| Applications : | Flow Cytometry |
Recombinant Monoclonal Antibody For Research Use Only
| Clonality : | Monoclonal |
| Host : | Human IgG1 Clone #Hu117 |
| Applications : | Flow Cytometry |
Recombinant Monoclonal Antibody For Research Use Only
| Clonality : | Monoclonal |
| Host : | Human IgG1 Clone #Hu143 |
| Applications : | Flow Cytometry |
Recombinant Monoclonal Antibody For Research Use Only
| Clonality : | Monoclonal |
| Host : | Human IgG1 Clone #Hu143 |
| Applications : | Flow Cytometry |
Recombinant Monoclonal Antibody For Research Use Only
| Clonality : | Monoclonal |
| Host : | Human IgG1 Clone #Hu117 |
| Applications : | Flow Cytometry |
Recombinant Monoclonal Antibody For Research Use Only
| Clonality : | Monoclonal |
| Host : | Human IgG1 Clone #Hu143 |
| Applications : | Flow Cytometry |
Recombinant Monoclonal Antibody For Research Use Only
| Clonality : | Monoclonal |
| Host : | Human IgG1 Clone #Hu143 |
| Applications : | Flow Cytometry |
Recombinant Monoclonal Antibody For Research Use Only
| Clonality : | Monoclonal |
| Host : | Human IgG1 Clone #Hu117 |
| Applications : | Flow Cytometry |
Recombinant Monoclonal Antibody For Research Use Only
| Clonality : | Monoclonal |
| Host : | Human IgG1 Clone #Hu117 |
| Applications : | Flow Cytometry |
Recombinant Monoclonal Antibody For Research Use Only
| Clonality : | Monoclonal |
| Host : | Human IgG1 Clone #Hu117 |
| Applications : | Flow Cytometry |
Recombinant Monoclonal Antibody For Research Use Only
| Clonality : | Monoclonal |
| Host : | Human IgG1 Clone #Hu143 |
| Applications : | Flow Cytometry |
Highly potent and selective inhibitor of integrin α4β1 (VLA-4)
| Chemical Name : | (2S)-2-[[[(2S)-1-[(3,5-Dichlorophenyl)sulfonyl]-2-pyrrolidinyl]carbonyl]amino]-4-[[(2S)-4-methyl-2-[methyl[2-[4-[[[(2-methylphenyl)amino]carbonyl]amino]phenyl]acetyl]amino]-1-oxopentyl]amino]butanoic acid |
| Purity : | ≥98% (HPLC) |
Dual α9β1/α4β1 integrin inhibitor; preferentially mobilizes HSCs
| Chemical Name : | N-(Benzenesulfonyl)-L-prolyl-L-O-(1-pyrrolidinylcarbonyl)tyrosine sodium salt |
| Purity : | ≥98% (HPLC) |
Fluorescent ligand for α4β1 (VLA-4)
| Purity : | ≥90% (HPLC) |
Potent integrin α4β7 and α4β1 (VLA-4) antagonist; orally bioavailable
| Chemical Name : | (αS)-α-[(2,6-Dichlorobenzoyl)amino]-2',6'-dimethoxy[1,1'-biphenyl]-4-propanoic acid |
| Purity : | ≥98% (HPLC) |
α4β1 (VLA-4) antagonist
| Chemical Name : | 1-[[(3S)-4-[2-[4-[[[(2-Methylphenyl)amino]carbonyl]amino]phenyl]acety]l-3-morpholinyl]carbonyl]-4-piperidinediacetic acid |
| Purity : | ≥98% (HPLC) |
