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Integrin alpha 4 beta 7/LPAM-1 Products

Integrin alpha 4 beta 7 (LPAM-1) is an integrin family adhesion receptor that shares subunits with VLA4 and the E-cadherin receptor. It is the non-covalent heterodimer of alpha 4/CD49d and beta 7 transmembrane subunits. Motifs within a4b7 bind to metal ions and regulate cell adhesion functions. a4b7 binds the mucosal addressin MAdCAM-1, as well as VCAM-1 and Fibronectin. The chemokine receptor CCR9 and a4b7, both critical for homing to intestinal mucosa, are induced during T cell activation in Peyer’s patches or mesenteric lymph nodes. a4b7-expressing Treg, memory T cells, and B cells home to the intestinal mucosa or the peritoneum. The HIV-1 envelope protein gp120 binds to the active form of a4b7 and may concentrate the virus in gut-associated lymphoid tissue (GALT).

26 results for "Integrin alpha 4 beta 7/LPAM-1" in Products

Integrin alpha 4 beta 7/LPAM-1 Products

Integrin alpha 4 beta 7 (LPAM-1) is an integrin family adhesion receptor that shares subunits with VLA4 and the E-cadherin receptor. It is the non-covalent heterodimer of alpha 4/CD49d and beta 7 transmembrane subunits. Motifs within a4b7 bind to metal ions and regulate cell adhesion functions. a4b7 binds the mucosal addressin MAdCAM-1, as well as VCAM-1 and Fibronectin. The chemokine receptor CCR9 and a4b7, both critical for homing to intestinal mucosa, are induced during T cell activation in Peyer’s patches or mesenteric lymph nodes. a4b7-expressing Treg, memory T cells, and B cells home to the intestinal mucosa or the peritoneum. The HIV-1 envelope protein gp120 binds to the active form of a4b7 and may concentrate the virus in gut-associated lymphoid tissue (GALT).

26 results for "Integrin alpha 4 beta 7/LPAM-1" in Products

Catalog #: 8615-A3
BA
Catalog #: FAB10548G
Flow

Recombinant Monoclonal Antibody For Research Use Only

Flow

Recombinant Monoclonal Antibody For Research Use Only

Flow

Recombinant Monoclonal Antibody For Research Use Only

Flow, CyTOF-ready

Recombinant Monoclonal Antibody For Research Use Only

Flow, CyTOF-ready

Recombinant Monoclonal Antibody For Research Use Only

Recombinant Monoclonal Antibody For Research Use Only

Catalog #: FAB10548S
Flow

Recombinant Monoclonal Antibody For Research Use Only

Flow

Recombinant Monoclonal Antibody For Research Use Only

Catalog #: FAB10548N
Flow

Recombinant Monoclonal Antibody For Research Use Only

Catalog #: FAB10548U
Flow

Recombinant Monoclonal Antibody For Research Use Only

Catalog #: FAB10078T
Flow

Recombinant Monoclonal Antibody For Research Use Only

Catalog #: FAB10548T
Flow

Recombinant Monoclonal Antibody For Research Use Only

Catalog #: FAB10548V
Flow

Recombinant Monoclonal Antibody For Research Use Only

Catalog #: FAB10078U
Flow

Recombinant Monoclonal Antibody For Research Use Only

Catalog #: FAB10078V
Flow

Recombinant Monoclonal Antibody For Research Use Only

Catalog #: FAB10078S
Flow

Recombinant Monoclonal Antibody For Research Use Only

Catalog #: FAB10548R
Flow

Recombinant Monoclonal Antibody For Research Use Only

Highly potent and selective inhibitor of integrin α4β1 (VLA-4)

Dual α9β1/α4β1 integrin inhibitor; preferentially mobilizes HSCs

α4β1 (VLA-4) ligand

Fluorescent ligand for α4β1 (VLA-4)

Potent integrin α4β7 and α4β1 (VLA-4) antagonist; orally bioavailable

α4β1 (VLA-4) antagonist

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