Integrin alpha 4 beta 7/LPAM-1: Proteins and Enzymes

Integrin alpha 4 beta 7 (LPAM-1) is an integrin family adhesion receptor that shares subunits with VLA4 and the E-cadherin receptor. It is the non-covalent heterodimer of alpha 4/CD49d and beta 7 transmembrane subunits. Motifs within a4b7 bind to metal ions and regulate cell adhesion functions. a4b7 binds the mucosal addressin MAdCAM-1, as well as VCAM-1 and Fibronectin. The chemokine receptor CCR9 and a4b7, both critical for homing to intestinal mucosa, are induced during T cell activation in ...