IL-21: Antibodies
IL-21 (Interleukin-21) is member of the family of cytokines that utilize the common gamma chain as a receptor subunit. This subunit is also a component of the receptors for IL-2, IL-4, IL-7, IL-9, and IL-15. IL-21 is produced by activated T follicular helper cells (Tfh), Th17 cells, and NKT cells. It exerts its biological effects through a heterodimeric receptor complex of the common gamma chain and the IL-21-specific IL-21 R. IL-21 supports Tfh cell development, immunoglobulin affinity maturation, plasma cell differentiation, B cell memory responses, and the migration of dendritic cells to draining lymph nodes. It costimulates the activation, proliferation, and survival of CD8+ T cells and NKT cells and promotes Th17 cell polarization. It blocks the generation of regulatory T cells and their suppressive effects on CD4+ T cells. In addition, IL-21 suppresses cutaneous hypersensitivity reactions by limiting allergen-specific IgE production and mast cell degranulation.
18 results for "IL-21 Primary Antibodies" in Products
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IL-21: Antibodies
IL-21 (Interleukin-21) is member of the family of cytokines that utilize the common gamma chain as a receptor subunit. This subunit is also a component of the receptors for IL-2, IL-4, IL-7, IL-9, and IL-15. IL-21 is produced by activated T follicular helper cells (Tfh), Th17 cells, and NKT cells. It exerts its biological effects through a heterodimeric receptor complex of the common gamma chain and the IL-21-specific IL-21 R. IL-21 supports Tfh cell development, immunoglobulin affinity maturation, plasma cell differentiation, B cell memory responses, and the migration of dendritic cells to draining lymph nodes. It costimulates the activation, proliferation, and survival of CD8+ T cells and NKT cells and promotes Th17 cell polarization. It blocks the generation of regulatory T cells and their suppressive effects on CD4+ T cells. In addition, IL-21 suppresses cutaneous hypersensitivity reactions by limiting allergen-specific IgE production and mast cell degranulation.
18 results for "IL-21 Primary Antibodies" in Products
Clonality : | Polyclonal |
Host : | Goat IgG |
Applications : | Block/Neutralize, ELISA Capture, Immunocytochemistry/Immunofluorescence, Western Blot |
Clonality : | Polyclonal |
Host : | Goat IgG |
Applications : | ELISA Detection, Western Blot |
Host : | Goat IgG |
Applications : | ELISA, Western Blot |
Clonality : | Monoclonal |
Host : | Rat IgG2b Clone #149204 |
Applications : | Flow Cytometry |
Clonality : | Monoclonal |
Host : | Rat IgG2b Clone #149204 |
Applications : | CyTOF-ready, Flow Cytometry, Western Blot |
Clonality : | Monoclonal |
Host : | Rat IgG2b Clone #149204 |
Applications : | Flow Cytometry |
Clonality : | Monoclonal |
Host : | Mouse IgG2a Clone #1004614 |
Applications : | ELISA |
Clonality : | Monoclonal |
Host : | Rat IgG2b Clone #149204 |
Applications : | Flow Cytometry |
Clonality : | Polyclonal |
Host : | Sheep IgG |
Applications : | Block/Neutralize |
Clonality : | Monoclonal |
Host : | Mouse IgG1 Clone #148002 |
Applications : | ELISA |
Clonality : | Monoclonal |
Host : | Rat IgG2b Clone #149204 |
Applications : | Flow Cytometry |
Clonality : | Monoclonal |
Host : | Rat IgG2b Clone #149204 |
Applications : | Flow Cytometry |
Clonality : | Monoclonal |
Host : | Rat IgG2b Clone #149204 |
Applications : | Flow Cytometry |
Clonality : | Monoclonal |
Host : | Rat IgG2b Clone #149204 |
Applications : | Flow Cytometry |
Clonality : | Monoclonal |
Host : | Rat IgG2b Clone #149204 |
Applications : | Flow Cytometry |
Clonality : | Monoclonal |
Host : | Rat IgG2b Clone #149204 |
Applications : | Flow Cytometry |
Clonality : | Monoclonal |
Host : | Mouse IgG2b Clone #1004603 |
Applications : | ELISA |
Clonality : | Monoclonal |
Host : | Mouse IgG1 Clone #1012733 |
Applications : | ELISA |