Skip to main content

IL-13 R alpha 1 Products

Two members of the type 5 subfamily of type I cytokine receptors can serve as receptors for IL-13. IL-13 can bind to IL-13 R alpha 1 (CD213a1; previously designated IL-13 R alpha or NR4) with low affinity, then recruits the IL-4 R alpha chain to form a high affinity receptor, causing downstream STAT6 activation. Alternately, IL-13 can bind IL-13 R alpha 2 (CD213a2) with high affinity; this interaction does not cause activation of STAT6, but does induce TGF-beta production. IL-13 R alpha 1 and IL-13 R alpha 2 each have three extracellular fibronectin type III domains, two cytokine receptor homology modules and a WSXWS motif typical of the class I cytokine receptor family, but IL-13 R alpha 2 has a much shorter cytoplasmic tail. IL-13 R subunits can be expressed on monocytes, macrophages, fibroblasts, human B cells, basophils, eosinophils, endothelial cells, and smooth muscle cells.

Show More

135 results for "IL-13 R alpha 1" in Products

Back to Search Results
Apply

Search

IL-13 R alpha 1 Products

Two members of the type 5 subfamily of type I cytokine receptors can serve as receptors for IL-13. IL-13 can bind to IL-13 R alpha 1 (CD213a1; previously designated IL-13 R alpha or NR4) with low affinity, then recruits the IL-4 R alpha chain to form a high affinity receptor, causing downstream STAT6 activation. Alternately, IL-13 can bind IL-13 R alpha 2 (CD213a2) with high affinity; this interaction does not cause activation of STAT6, but does induce TGF-beta production. IL-13 R alpha 1 and IL-13 R alpha 2 each have three extracellular fibronectin type III domains, two cytokine receptor homology modules and a WSXWS motif typical of the class I cytokine receptor family, but IL-13 R alpha 2 has a much shorter cytoplasmic tail. IL-13 R subunits can be expressed on monocytes, macrophages, fibroblasts, human B cells, basophils, eosinophils, endothelial cells, and smooth muscle cells.

Show More

135 results for "IL-13 R alpha 1" in Products

WB, Flow, IHC, CyTOF-ready, Neut
WB, Flow, CyTOF-ready
BA
BA
WB
BA

Biotinylated

Flow
Flow
ELISA
Catalog #: FAB1462G
Flow
Catalog #: FAB1462T
Flow
Catalog #: FAB1462U
Flow
Catalog #: FAB1462R
Flow
Catalog #: FAB1462S
Flow
Catalog #: FAB1462V
Flow
Catalog #: RDC1305
Catalog #: RDC1357
IHC, WB
ELISA

Recombinant Monoclonal Antibody

IHC, WB

Recombinant Monoclonal Antibody

Results Per Page
5 10 25 50
/ 6