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Hip: Lysates
Hedgehog-interacting protein (Hip) is a type I transmembrane protein that binds all three mammalian Hedgehogs: Sonic (Shh), Desert (Dhh), and Indian (Ihh). Hip is expressed in a variety of organs, adjacent to sites of Hedgehog expression where it regulates the availability of Hedgehog ligand extracellularly and acts as a potent antagonist of Hedgehog signaling.
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