GPR89: Proteins and Enzymes

The Golgi pH regulator (A or B) protein encoded by the GPR89 gene functions as a voltage dependent anion channel. The GPR89 gene and coded proteins are necessary for acidification and works of the Golgi apparatus in counter-ion conductance. Three isoforms encoded by the GPR89 gene exist: Isoform 1 is 455 amino acids long, nearly 53 kDA; isoform 2 is 335 amino acids in length at 38 kDA; and isoform 3 exists at 430 amino acids and just under 50 kDA. GPR89 interacts with the CLN3 as well as UBC genes.