Fibulin 5/DANCE: Proteins and Enzymes

Fibulin 5, also known as DANCE and EVEC, is a secreted matricellular glycoprotein that is expressed by smooth muscle cells and endothelial cells of the developing vasculature as well as by migrating neural crest cells and lung interstitial fibroblasts. It is downregulated in the adult vasculature but is re-expressed at aortic branching points, in the uterus, and at sites of mechanical or atherosclerotic injury. Fibulin 5 anchors cells to the extracellular matrix, promotes elastic fiber assembly ...