F-Spondin/SPON1: Proteins and Enzymes

F-Spondin is a secreted protein expressed at high levels in the embryonic floor plate. The ECM-attached protein plays a dual role in patterning the nervous system; it promotes outgrowth of commissural axons and inhibits outgrowth of motor axons. F-Spondin contains six thrombospondin repeats which interact with the apolipoprotein E receptor.

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