Dopamine beta-Hydroxylase: Proteins and Enzymes

Dopamine β-hydroxylase (DβH; also dopamine β-monooxygenase) is a 73 - 77 kDa member of the copper type II ascorbate-dependent monooxygenase family. It is both soluble (73 kDa) and membrane-bound (77 kDa) (anchored by an uncleaved signal sequence), and via hydroxylation, converts dopamine into norepinepherine.

Human DβH is a copper-containing disulfide-linked homodimer that is found in neurons and adrenal medullary cells. It is 603 amino acids (aa) in length and contains ...