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CRTAM: Antibodies

CRTAM (Class I-restricted T cell-associated molecule) is a nectin family member of the immunoglobulin superfamily that is expressed by activated CD8+ and NK T cells. NK activation receptor engagement, but not cytokines, also induce NK CRTAM expression. CRTAM is found in spleen, thymus, small intestine, peripheral blood, and in brain where it is highly expressed by Purkinje cells of the cerebellum.

Human CRTAM is a 393 amino acid (aa), 80 kDa type I transmembrane glycoprotein. CRTAM is a homodimer on the cell surface but does not show homotypic binding in trans. The high affinity of CRTAM/IGSF4 adhesion allows CRTAM to disrupt IGSF4 homotypic interactions. IGSF4 and T cell receptor co-engagement of CRTAM-expressing CD8+ cells induces increased IFN-gamma or IL-22 production. A role in cancer surveillance through NK cell-mediated rejection of IGSF4-expressing tumors has been proposed. IGSF4 is expressed broadly, including on epithelia, neurons, a subset of tonsillar B cells and a rare splenic T zone-restricted BCDA3+ dendritic cell population which interacts with CRTAM.

13 results for "CRTAM Primary Antibodies" in Products

CRTAM: Antibodies

CRTAM (Class I-restricted T cell-associated molecule) is a nectin family member of the immunoglobulin superfamily that is expressed by activated CD8+ and NK T cells. NK activation receptor engagement, but not cytokines, also induce NK CRTAM expression. CRTAM is found in spleen, thymus, small intestine, peripheral blood, and in brain where it is highly expressed by Purkinje cells of the cerebellum.

Human CRTAM is a 393 amino acid (aa), 80 kDa type I transmembrane glycoprotein. CRTAM is a homodimer on the cell surface but does not show homotypic binding in trans. The high affinity of CRTAM/IGSF4 adhesion allows CRTAM to disrupt IGSF4 homotypic interactions. IGSF4 and T cell receptor co-engagement of CRTAM-expressing CD8+ cells induces increased IFN-gamma or IL-22 production. A role in cancer surveillance through NK cell-mediated rejection of IGSF4-expressing tumors has been proposed. IGSF4 is expressed broadly, including on epithelia, neurons, a subset of tonsillar B cells and a rare splenic T zone-restricted BCDA3+ dendritic cell population which interacts with CRTAM.

13 results for "CRTAM Primary Antibodies" in Products

WB, Flow, CyTOF-ready

Clone 210213 was used by HLDA to establish CD designation

Catalog #: BAF1695
WB
Catalog #: FAB16951R
Flow

Clone 210213 was used by HLDA to establish CD designation

Catalog #: FAB16951N
Flow

Clone 210213 was used by HLDA to establish CD designation

Flow

Clone 210213 was used by HLDA to establish CD designation

Catalog #: FAB16951V
Flow

Clone 210213 was used by HLDA to establish CD designation

Flow

Clone 210213 was used by HLDA to establish CD designation

Catalog #: FAB16951G
Flow

Clone 210213 was used by HLDA to establish CD designation

Catalog #: FAB16951U
Flow

Clone 210213 was used by HLDA to establish CD designation

Catalog #: FAB16951T
Flow

Clone 210213 was used by HLDA to establish CD designation

Clone 210213 was used by HLDA to establish CD designation

Catalog #: MAB1695
WB
WB
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