COUP-TF I/NR2F1: Proteins and Enzymes

Chicken ovalbumin upstream promoter transcription factor I (COUP-TF I, EAR3, COUP-TFA; NR2F1) is a member of the orphan nuclear receptor family. COUP-TF I is expressed in specific regions of the rostral brain. COUP-TF I has varied roles in the development of the peripheral nervous system, such as early regionalization of the neocortex, differentiation of subplate neurons and guidance of thalamocortical axons. COUP-TFs have been shown to interact with a number of other nuclear receptors.