COPR5: Proteins and Enzymes

COPR5 is a Histone-binding protein required for histone H4 methyltransferase activity of PRMT5. Specifically required for histone H4 'Arg-3' methylation mediated by PRMT5, but not histone H3 'Arg-8' methylation, suggesting that it modulates the substrate specificity of PRMT5. Specifically interacts with the N-terminus of histone H4 but not with histone H3, suggesting that COPR5 acts by promoting the association between histone H4 and PRMT5. Involved in CCNE1 promoter repression.