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CFTR Products
Cystic fibrosis transmembrane conductance regulator (CFTR) is a multi-pass transmembrane protein that functions as a chloride channel. CFTR belongs to the ATP-binding cassette (ABC) superfamily. Mutations in CFTR cause the pulmonary disease, cystic fibrosis (CF). Specifically, deletion of phenyalanine at position 508 (DeltaF508-CFTR) results in a folding defect which impairs chloride channel function. The mechanism by which channel dysfunction relates to disease symptoms is a focus of intense research. CFTR dysfunction results in disruption of ion transport and subsequent blockage of airways by secreted mucus. CFTR may also play a role in the skeletal muscle atrophy and dysfunction that characterizes CF. In addition, CFTR-mediated chloride secretion underlies fluid accumulation and cyst growth in autosomal dominant polycystic kidney disease (ADPKD).
7 results for "CFTR" in Products
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CFTR Products
Cystic fibrosis transmembrane conductance regulator (CFTR) is a multi-pass transmembrane protein that functions as a chloride channel. CFTR belongs to the ATP-binding cassette (ABC) superfamily. Mutations in CFTR cause the pulmonary disease, cystic fibrosis (CF). Specifically, deletion of phenyalanine at position 508 (DeltaF508-CFTR) results in a folding defect which impairs chloride channel function. The mechanism by which channel dysfunction relates to disease symptoms is a focus of intense research. CFTR dysfunction results in disruption of ion transport and subsequent blockage of airways by secreted mucus. CFTR may also play a role in the skeletal muscle atrophy and dysfunction that characterizes CF. In addition, CFTR-mediated chloride secretion underlies fluid accumulation and cyst growth in autosomal dominant polycystic kidney disease (ADPKD).
7 results for "CFTR" in Products
| Clonality : | Monoclonal |
| Host : | Mouse IgG2a Clone #24-1 |
| Applications : | Immunohistochemistry, Immunoprecipitation, Western Blot |
Voltage-independent, selective CFTR chloride channel blocker
| Chemical Name : | 4-[[4-Oxo-2-thioxo-3-[3-trifluoromethyl)phenyl]-5-thiazolidinylidene]methyl]benzoic acid |
| Purity : | ≥98% (HPLC) |
Potent, voltage-independent CFTR chloride channel inhibitor
| Chemical Name : | 6,7-Dihydro-7,9-dimethyl-6-(5-methyl-2-furanyl)-11-phenylpyrimido[4',5':3,4]pyrrolo[1,2-a]quinoxaline-8,10(5H,9)-dione |
| Purity : | ≥98% (HPLC) |
Inhibits calcium-sensitive chloride currents
| Chemical Name : | 5-Nitro-2-(3-phenylpropylamino)benzoic acid |
| Purity : | ≥99% (HPLC) |
Reversible, voltage-dependent CFTR chloride channel blocker
| Chemical Name : | N-2-Naphthalenyl-2-[(3,5-dibromo-2,4-dihydroxyphenyl)methylene]glycine hydrazide |
| Purity : | ≥98% (HPLC) |
Activates Cl- conductance and hKCa3.1 channels
| Chemical Name : | 5,6-Dichloro-1-ethyl-1,3-dihydro-2H-benzimidazol-2-one |
| Purity : | ≥99% (HPLC) |
| Clonality : | Monoclonal |
| Host : | Mouse IgG1 Clone #13-1 |
| Applications : | Immunocytochemistry/Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blot |
