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CD47: Antibodies

CD47, also known as Integrin-Associated Protein (IAP) and OA3, is a ubiquitous transmembrane protein that binds to SIRP family members on macrophages, neutrophils, and T cells. These interactions prevent macrophage-mediated clearance of healthy CD47-expressing cells and promote immune cell transmigration across the vascular endothelium. CD47 associates in cis with Fas on T cells and enhances Fas-mediated apoptosis; its ligation promotes T cell anergy and dampens Th1 immune responses. CD47 also associates in cis with several Integrins which can positively or negatively modulate Integrin-mediated function. CD47 binding by Thrombospondin-1 inhibits the angiogenic and vasorelaxant effects of nitric oxide. On dendritic cells and myeloma cells, CD47 ligation by TSP-1 induces giant cell formation and osteoclast differentiation.

29 results for "CD47 Primary Antibodies" in Products

CD47: Antibodies

CD47, also known as Integrin-Associated Protein (IAP) and OA3, is a ubiquitous transmembrane protein that binds to SIRP family members on macrophages, neutrophils, and T cells. These interactions prevent macrophage-mediated clearance of healthy CD47-expressing cells and promote immune cell transmigration across the vascular endothelium. CD47 associates in cis with Fas on T cells and enhances Fas-mediated apoptosis; its ligation promotes T cell anergy and dampens Th1 immune responses. CD47 also associates in cis with several Integrins which can positively or negatively modulate Integrin-mediated function. CD47 binding by Thrombospondin-1 inhibits the angiogenic and vasorelaxant effects of nitric oxide. On dendritic cells and myeloma cells, CD47 ligation by TSP-1 induces giant cell formation and osteoclast differentiation.

29 results for "CD47 Primary Antibodies" in Products

WB, Flow, IHC, CyTOF-ready, KO, Neut
Flow, Block, CyTOF-ready
Flow
Catalog #: FAB4670S
Flow
WB, Flow, IHC
Flow, Block, CyTOF-ready
Flow, CyTOF-ready
Flow
Catalog #: FAB4670R
Flow
Catalog #: FAB4670N
Flow
Catalog #: FAB4670T
Flow
Catalog #: FAB4670U
Flow
Catalog #: FAB1866V
Flow
Catalog #: FAB1866U
Flow
Catalog #: FAB1866G
Flow
Catalog #: FAB1866R
Flow
Catalog #: FAB1866S
Flow
Catalog #: FAB1866T
Flow
Catalog #: FAB1866N
Flow
Catalog #: FAB18661G
Flow
Catalog #: FAB18661U
Flow
Catalog #: FAB18661N
Flow
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