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8 results for "Caspase-8" in Products
Caspase-8 Products
Caspase-8, also known as MCH5, FLICA and MACH alpha 1, is a 28 kDa member of the peptidase C14A family of enzymes. It is widely expressed and is considered an initiating caspase for the apoptotic cascade. Caspase-8 acts on a wide variety of substrates including Pro-Caspases-3, -4, -6, -7, -9 and -10, c-FLIPL and Pro-Caspase‑8 itself. Caspase-8 is recruited to the death-inducing signaling complex (DISC) that forms around the death domains of the oligomerized receptors. Multiple rounds of cleavage generate Caspase-8 p10 and p18 which heterodimerize and then associate into the active tetrameric enzyme containing two p10 and two p18 subunits.
Reactivity:
Human, Primate
Details:
Mouse IgG1 Monoclonal Clone #90A992
Applications:
IHC, WB, Flow, CyTOF-ready
Reactivity:
Human, Mouse
Details:
Rabbit IgG Polyclonal
Applications:
WB
Reactivity:
Human, Mouse
Details:
Goat IgG Polyclonal
Applications:
KO, WB
Reactivity:
Human
Details:
Mouse IgG2A Monoclonal Clone #84131
Applications:
WB
Reactivity:
Human
Details:
Mouse IgG1 Monoclonal Clone #746109
Applications:
ICC/IF
Reactivity:
Human, Mouse, Rat
Details:
Rabbit IgG Polyclonal
Applications:
IHC, WB, ELISA, ICC/IF
Reactivity:
Mouse
Details:
Rat IgG1 kappa Monoclonal Clone #3B10
Applications:
IHC, WB, ELISA, Flow, ICC/IF
Reactivity:
Mouse
Details:
Rat IgG1 kappa Monoclonal Clone #1G12
Applications:
IHC, WB, ELISA, Flow
