Calreticulin: Proteins and Enzymes

Calreticulin is a multifunctional, intracellular calcium-binding protein that is found in most eukaryotic cells. It serves as a key regulator of intracellular free calcium levels. Calreticulin also functions as a lectin-type chaperone in the endoplasmic reticulum (ER). It binds to oligosaccharide residues on newly synthesized glycoproteins to ensure proper folding and retains non-native protein conformers within the ER where they are targeted for degradation. Calreticulin has also been ...