BMP-6 Products
BMP-6 (Bone Morphogenetic Protein 6) forms disulfide-linked homodimers and heterodimers with BMP-2 that signal through complexes of type I (Activin RIA/ALK-2 and BMPR-IA/ALK-3) and type II (Activin RIIA and BMPR-II) receptors. BMP-6 promotes osteoblast differentiation from mesenchymal stem cells, chondrocyte maturation, Ang II-induced aldosterone production in the adrenal cortex, and hormone production and responsiveness in ovarian granulosa cells. It promotes neurite outgrowth, neuroprotection, angiogenesis, immune tolerance, and tumor progression. BMP-6 binds to RGM-C/Hemojuvelin to enhance Hepcidin expression and prevent serum iron overload. Heterodimers of BMP-2 and BMP-6 show increased potency at inducing bone formation compared to either BMP-2 or BMP-6 homodimers.
168 results for "BMP-6" in Products
168 results for "BMP-6" in Products
BMP-6 Products
BMP-6 (Bone Morphogenetic Protein 6) forms disulfide-linked homodimers and heterodimers with BMP-2 that signal through complexes of type I (Activin RIA/ALK-2 and BMPR-IA/ALK-3) and type II (Activin RIIA and BMPR-II) receptors. BMP-6 promotes osteoblast differentiation from mesenchymal stem cells, chondrocyte maturation, Ang II-induced aldosterone production in the adrenal cortex, and hormone production and responsiveness in ovarian granulosa cells. It promotes neurite outgrowth, neuroprotection, angiogenesis, immune tolerance, and tumor progression. BMP-6 binds to RGM-C/Hemojuvelin to enhance Hepcidin expression and prevent serum iron overload. Heterodimers of BMP-2 and BMP-6 show increased potency at inducing bone formation compared to either BMP-2 or BMP-6 homodimers.
| Source: | NS0 |
| Accession #: | P22004 |
| Applications: | BA |
| Source: | CHO |
| Accession #: | P20722 |
| Applications: | BA |
| Reactivity: | Human |
| Details: | Mouse IgG2b Monoclonal Clone #74219 |
| Applications: | WB, Neut |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, IHC, Neut |
| Assay Range: | 156 - 10,000 pg/mL |
| Applications: | ELISA |
| Source: | CHO |
| Accession #: | Q04906.2 |
| Applications: | BA |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB |
| Reactivity: | Mouse |
| Details: | Sheep IgG Polyclonal |
| Applications: | WB, IHC |
| Reactivity: | Mouse |
| Details: | Rat IgG2b Monoclonal Clone #719040 |
| Applications: | Neut |
| Source: | E. coli |
| Accession #: | P12643 (BMP-2) & P22004 (BMP-6) |
| Applications: | BA |
| Reactivity: | Mouse |
| Details: | Sheep IgG Polyclonal |
| Applications: | WB, IHC |
| Reactivity: | Mouse |
| Details: | Sheep IgG Polyclonal |
| Applications: | WB, IHC |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, IHC, Neut |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, IHC, Neut |
| Reactivity: | Human |
| Details: | Mouse IgG2b Monoclonal Clone #74219 |
| Applications: | WB, ELISA(Cap), ELISA(Det), Neut |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, IHC, Neut |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, IHC, Neut |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, IHC, Neut |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, IHC, Neut |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, IHC, Neut |
| Reactivity: | Mouse |
| Details: | Sheep IgG Polyclonal |
| Applications: | WB, IHC |
| Reactivity: | Mouse |
| Details: | Sheep IgG Polyclonal |
| Applications: | WB, IHC |
| Reactivity: | Mouse |
| Details: | Sheep IgG Polyclonal |
| Applications: | WB, IHC |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, IHC, Neut |
| Reactivity: | Mouse |
| Details: | Sheep IgG Polyclonal |
| Applications: | WB, IHC |