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4 results for "Bcl-2" in Products
Bcl-2 Products
Bcl-2 is a member of a family of proteins that regulates outer mitochondrial membrane permeability. Bcl-2 is an anti-apoptotic member that prevents release of cytochrome c from the mitochondria intermembrane space into the cytosol. Bcl-2 is present on the outer mitochondrial membrane and is also found on other membranes in some cell types. Natural Bcl-2 contains a carboxyl-terminal mitochondria targeting sequence.
Selective, high affinity Bcl-2 inhibitor; orally bioavailable
Alternate Names:
Venetoclax,GDC-0199
Chemical Name:
4-[4-[[2-(4-Chlorophenyl)-4,4-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[3-nitro-4-[[(tetrahydro-2H-pyran-4-yl)methyl]amino]phenyl]sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide
Purity:
≥98%
Bcl-2 family inhibitor; mimics BH3 and induces apoptosis in cancer cell lines
Chemical Name:
4-[4-[(4'-Chloro[1,1'-biphenyl]-2-yl)methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(dimethylamino)-1-[(phenylthio)methyl]propyl]amino]-3-nitrophenyl]sulfonyl]benzamide
Purity:
≥97%
Inhibitor of Bcl-2 family members; antiapoptotic
Alternate Names:
GX15-070
Chemical Name:
2-[2-[(3,5-Dimethyl-1H-pyrrol-2-yl)methylene)-3-methoxy-2H-pyrrol-5-yl]-1H-indole methanesulfonate
Purity:
≥98%
Inhibitor of Bcl-2 family members; antiapoptotic
Alternate Names:
GX15-070
Chemical Name:
2-[2-[(3,5-Dimethyl-1H-pyrrol-2-yl)methylene)-3-methoxy-2H-pyrrol-5-yl]-1H-indole methanesulfonate
Purity:
≥98%