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BACE-1 Products
Both BACE-1 and BACE-2 are membrane-bound aspartic proteases of the pepsin family. BACE-1 is a potential target for treatment of Alzheimer's disease because it is the principle b-secretase responsible for cleavage of amyloid precursor protein (APP). BACE-2 differs from BACE-1 in several aspects including pro-enzyme activation, substrate binding sites, transcriptional regulation, and function in A beta peptide production.
18 results for "BACE-1" in Products
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BACE-1 Products
Both BACE-1 and BACE-2 are membrane-bound aspartic proteases of the pepsin family. BACE-1 is a potential target for treatment of Alzheimer's disease because it is the principle b-secretase responsible for cleavage of amyloid precursor protein (APP). BACE-2 differs from BACE-1 in several aspects including pro-enzyme activation, substrate binding sites, transcriptional regulation, and function in A beta peptide production.
18 results for "BACE-1" in Products
BACE1 and BACE2 inhibitor
| Chemical Name : | N-[3-[(5R)-3-Amino-5,6-dihydro-2,5-dimethyl-1,1-dioxido-2H-1,2,4-thiadiazin-5-yl]-4-fluorophenyl]-5-fluoro-2-pyridinecarboxamide |
| Purity : | ≥98% (HPLC) |
| Clonality : | Monoclonal |
| Host : | Mouse IgG1 Clone #137612 |
| Applications : | CyTOF-ready, Flow Cytometry, Immunohistochemistry, Western Blot |
| Source : | NS0 |
| Accession # : | P56817.1 |
| Applications : | Enzyme Activity |
Contains 4 membranes - 2 spotted in duplicate with 62 different non-hematopoietic antibodies and 2 spotted in duplicate with 57 common antibodies
| Assay Range : | 0.625 - 40 ng/mL |
| Applications : | ELISA |
| Clonality : | Monoclonal |
| Host : | Mouse IgG1 Clone #137626 |
| Applications : | Block/Neutralize, Immunoprecipitation |
| Source : | NS0 |
| Accession # : | P56818 |
| Applications : | Enzyme Activity |
| Clonality : | Polyclonal |
| Host : | Goat IgG |
| Applications : | Western Blot |
| Clonality : | Polyclonal |
| Host : | Goat IgG |
| Applications : | Immunoprecipitation, Western Blot |
| Clonality : | Monoclonal |
| Host : | Mouse IgG1 Clone #137612 |
| Applications : | Flow Cytometry |
| Clonality : | Monoclonal |
| Host : | Mouse IgG1 Clone #137612 |
| Applications : | Flow Cytometry |
| Clonality : | Monoclonal |
| Host : | Mouse IgG1 Clone #137612 |
| Applications : | Flow Cytometry |
| Clonality : | Monoclonal |
| Host : | Mouse IgG1 Clone #137612 |
| Applications : | Flow Cytometry |
| Clonality : | Monoclonal |
| Host : | Mouse IgG1 Clone #137612 |
| Applications : | Flow Cytometry |
| Clonality : | Monoclonal |
| Host : | Mouse IgG1 Clone #137612 |
| Applications : | Flow Cytometry |
| Clonality : | Monoclonal |
| Host : | Mouse IgG1 Clone #137612 |
| Applications : | Flow Cytometry |
Potent and selective β-secretase (BACE) inhibitor
| Chemical Name : | N-[3-[(4aS,7aS)-2-Amino-4a,5-dihydro-4H-furo[3,4-d][1,3]thiazin-7a(7H)-yl]-4-fluorophenyl]-5-fluoro-2-pyridinecarboxamide hydrochloride |
| Purity : | ≥98% (HPLC) |
