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APAF-1 Products
APAF-1, the human homolog of C. elegans CED-4, is a 130 kDa cytosolic protein that participates in the Cytochrome c-dependent activation of Caspase-3. The intrinsic Caspase activation pathway is activated by the release of mitochondrial Cytochrome c. This induces the cytosolic assembly of the apoptosome, a Caspase-activation complex involving Cytochrome c, APAF-1, and Caspase-9. Once activated, Caspase-9 can initiate a biochemical cascade involving activation of the downstream executioner Caspases-3, -6, and-7.
2 results for "APAF-1" in Products
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APAF-1 Products
APAF-1, the human homolog of C. elegans CED-4, is a 130 kDa cytosolic protein that participates in the Cytochrome c-dependent activation of Caspase-3. The intrinsic Caspase activation pathway is activated by the release of mitochondrial Cytochrome c. This induces the cytosolic assembly of the apoptosome, a Caspase-activation complex involving Cytochrome c, APAF-1, and Caspase-9. Once activated, Caspase-9 can initiate a biochemical cascade involving activation of the downstream executioner Caspases-3, -6, and-7.
2 results for "APAF-1" in Products
| Clonality : | Monoclonal |
| Host : | Mouse IgG2b Clone #94408 |
| Applications : | Western Blot |
Promotes apoptosome formation and activates caspase-9/caspase-3 pathway. Selectively induces tumor cell apoptosis
| Chemical Name : | 1-[(3,4-Dichlorophenyl)methyl]-1H-indole-2,3-dione |
| Purity : | ≥99% (HPLC) |
