APAF-1 Products
APAF-1, the human homolog of C. elegans CED-4, is a 130 kDa cytosolic protein that participates in the Cytochrome c-dependent activation of Caspase-3. The intrinsic Caspase activation pathway is activated by the release of mitochondrial Cytochrome c. This induces the cytosolic assembly of the apoptosome, a Caspase-activation complex involving Cytochrome c, APAF-1, and Caspase-9. Once activated, Caspase-9 can initiate a biochemical cascade involving activation of the downstream executioner Caspases-3, -6, and-7.
136 results for "APAF-1" in Products
136 results for "APAF-1" in Products
APAF-1 Products
APAF-1, the human homolog of C. elegans CED-4, is a 130 kDa cytosolic protein that participates in the Cytochrome c-dependent activation of Caspase-3. The intrinsic Caspase activation pathway is activated by the release of mitochondrial Cytochrome c. This induces the cytosolic assembly of the apoptosome, a Caspase-activation complex involving Cytochrome c, APAF-1, and Caspase-9. Once activated, Caspase-9 can initiate a biochemical cascade involving activation of the downstream executioner Caspases-3, -6, and-7.
| Reactivity: | Human |
| Details: | Mouse IgG2b Monoclonal Clone #94408 |
| Applications: | WB |
| Reactivity: | Human, Mouse, Rat, Gerbil |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB, ICC/IF, IP |
![Western Blot: APAF-1 Antibody [NB100-56074]](https://resources.bio-techne.com/images/products/APAF1-Antibody-Western-Blot-NB100-56074-img0004.jpg "Western Blot: APAF-1 Antibody [NB100-56074]")
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC |
![Immunohistochemistry-Paraffin: APAF-1 Antibody [NBP1-89050]](https://resources.bio-techne.com/images/products/APAF-1-Antibody-Immunohistochemistry-Paraffin-NBP1-89050-img0005.jpg "Immunohistochemistry-Paraffin: APAF-1 Antibody [NBP1-89050]")
| Reactivity: | Human |
| Details: | Rat IgG2a Kappa Monoclonal Clone #2E12 |
| Applications: | IHC, WB, ELISA, ICC/IF, IP |
![Western Blot: APAF-1 Antibody (2E12)BSA Free [NBP2-80092]](https://resources.bio-techne.com/images/products/APAF-1-Antibody-2E12-Western-Blot-NBP2-80092-img0001.jpg "Western Blot: APAF-1 Antibody (2E12)BSA Free [NBP2-80092]")
| Reactivity: | Human |
| Details: | Mouse IgG2b Monoclonal Clone #94408 |
| Applications: | WB |
| Reactivity: | Human |
| Details: | Mouse IgG2b Monoclonal Clone #94408 |
| Applications: | WB |
| Reactivity: | Human |
| Details: | Mouse IgG2b Monoclonal Clone #94408 |
| Applications: | WB |
| Reactivity: | Human |
| Details: | Mouse IgG2b Monoclonal Clone #94408 |
| Applications: | WB |
| Reactivity: | Human |
| Details: | Mouse IgG2b Monoclonal Clone #94408 |
| Applications: | WB |
| Reactivity: | Human |
| Details: | Mouse IgG2b Monoclonal Clone #94408 |
| Applications: | WB |
| Reactivity: | Human |
| Details: | Mouse IgG2b Monoclonal Clone #94408 |
| Applications: | WB |
| Reactivity: | Human |
| Details: | Mouse IgG2b Monoclonal Clone #94408 |
| Applications: | WB |
| Reactivity: | Human |
| Details: | Mouse IgG2B Monoclonal Clone #2H9A1 |
| Applications: | WB, ELISA, ICC/IF, Flow |
![Western Blot: APAF-1 Antibody (2H9A1)BSA Free [NBP2-61868]](https://resources.bio-techne.com/images/products/APAF-1-Antibody-2H9A1-Western-Blot-NBP2-61868-img0004.jpg "Western Blot: APAF-1 Antibody (2H9A1)BSA Free [NBP2-61868]")
| Applications: | ELISA |
| Reactivity: | Human, Mouse |
| Details: | Rat IgG2a Kappa Monoclonal Clone #18H2 |
| Applications: | WB, ELISA, ICC/IF, IP |
![Western Blot: APAF-1 Antibody (18H2)BSA Free [NBP2-80094]](https://resources.bio-techne.com/images/products/APAF-1-Antibody-18H2-BSA-Free-Western-Blot-NBP2-80094-img0001.jpg "Western Blot: APAF-1 Antibody (18H2)BSA Free [NBP2-80094]")
| Applications: | AC |
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC |
![Immunohistochemistry-Paraffin: APAF-1 Antibody [NBP2-15420]](https://resources.bio-techne.com/images/products/APAF-1-Antibody-Immunohistochemistry-Paraffin-NBP2-15420-img0004.jpg "Immunohistochemistry-Paraffin: APAF-1 Antibody [NBP2-15420]")
Promotes apoptosome formation and activates caspase-9/caspase-3 pathway. Selectively induces tumor cell apoptosis
| Chemical Name: | 1-[(3,4-Dichlorophenyl)methyl]-1H-indole-2,3-dione |
| Purity: | ≥98% (HPLC) |
| Applications: | ELISA |
| Applications: | AC |
![Western Blot: APAF-1 Antibody Blocking Peptide [NBP1-77000PEP]](https://resources.bio-techne.com/images/products/APAF1-Peptide-Western-Blot-NBP1-77000PEP-img0001.jpg "Western Blot: APAF-1 Antibody Blocking Peptide [NBP1-77000PEP]")
| Applications: | ELISA |
| Reactivity: | Mouse, Rat |
| Details: | Rat IgG2a Kappa Monoclonal Clone #13F11 |
| Applications: | WB, ELISA, ICC/IF, IP |
![Western Blot: APAF-1 Antibody (13F11)BSA Free [NBP2-80093]](https://resources.bio-techne.com/images/products/APAF-1-Antibody-13F11-BSA-Free-Western-Blot-NBP2-80093-img0001.jpg "Western Blot: APAF-1 Antibody (13F11)BSA Free [NBP2-80093]")
| Reactivity: | Mouse, Rat |
| Details: | Rat IgG2a Kappa Monoclonal Clone #13F11 |
| Applications: | WB, ELISA, ICC/IF, IP |
| Applications: | WB, ELISA, MA, AP |
![SDS-PAGE: Recombinant Human APAF-1 GST (N-Term) Protein [H00000317-Q01]](https://resources.bio-techne.com/images/products/Recombinant-Human-APAF-1-Protein-SDS-Page-H00000317-Q01-img0001.jpg "SDS-PAGE: Recombinant Human APAF-1 GST (N-Term) Protein [H00000317-Q01]")
| Applications: | WB |
![Western Blot: APAF-1 Overexpression Lysate [NBP2-04870]](https://resources.bio-techne.com/images/products/APAF1-Overexpression-Lysate-Adult-Normal-Western-Blot-NBP2-04870-img0001.jpg "Western Blot: APAF-1 Overexpression Lysate [NBP2-04870]")